Publications by authors named "S R Brunnert"

Article Synopsis
  • Exposure to chronic constant hypoxia (CCH) and chronic intermittent hypoxia (CIH) affects growth and development in CD1 mice differently, with CCH leading to greater reductions in liver and kidney weight compared to CIH.
  • Both types of hypoxia resulted in significant slower weight gain, with CIH and CCH mice having 12% and 23% lower body weight respectively by postnatal day 30.
  • Heart weight increased in both hypoxic groups due to larger cardiomyocytes, but brain weight remained relatively unaffected.
View Article and Find Full Text PDF

Objective: Our purpose was to develop a mouse model of renal abscess to study the effect of extrauterine infection on preterm delivery.

Methods: Escherichia coli or sterile medium was injected into the left kidney of 70 pregnant mice that had completed approximately 75% of gestation. Preterm delivery rates were recorded for various inocula.

View Article and Find Full Text PDF

Background: Infection remains the single most important challenge to extended left ventricular assist device (LVAD) use and often arises from the percutaneous driveline exit site. We evaluated the ability of an LVAD driveline prototype impregnated with chlorhexidine, triclosan, and silver sulfadiazine to resist bacterial and fungal colonization.

Methods: The spectrum and duration of antimicrobial activity were evaluated in vitro by daily transfer of driveline segments embedded on agar plates inoculated with 10(8) colony-forming units (CFU) of Staphylococcus aureus (S.

View Article and Find Full Text PDF

Objective: To characterize the expression of inflammatory cytokines in a murine model of preterm delivery induced by heat-killed bacteria.

Methods: The right uterine horns of female CD-1 mice on day 14.5 of 19-20 days of gestation were inoculated with either sterile media or killed Escherichia coli bacteria (10(5)-10(10) organisms per mouse).

View Article and Find Full Text PDF

Dystrophic cardiac calcinosis (DCC) occurs in certain inbred strains of mice, including DBA/2 and C3H/He, and is generally found as an incidental lesion in adult animals at necropsy. Preliminary genetic studies into the cause of DCC have been performed in DBA/2 mice and suggest that DCC is inherited as an autosomal recessive trait involving three or four unlinked genes. To investigate the genetics of DCC further, we produced myocardial cell death by freeze-thaw injury to induce DCC.

View Article and Find Full Text PDF