Publications by authors named "S Quesada-Bernat"
Lataste's viper (Vipera latastei) is a venomous European viper endemic to the Iberian Peninsula, recognised as medically important by the World Health Organization. To date, no comprehensive characterisation of this species' venom has been reported. Here, we analysed the venoms of juvenile and adult specimens of V.
View Article and Find Full Text PDFCobras are the most medically important elapid snakes in Africa. The African genera Naja and Hemachatus include snakes with neurotoxic and cytotoxic venoms, with shared biochemical, toxinological and antigenic characteristics. We have studied the antigenic cross-reactivity of four sub-Saharan Africa cobra venoms against an experimental monospecific Hemachatus haemachatus antivenom through comparative proteomics, preclinical assessment of neutralization, and third generation antivenomics.
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- The study characterizes the venoms of two subspecies of the South American palm pit viper, highlighting their proteomic profiles and components that contribute to their toxicity.
- The venoms contain proteins from 11 classes, with significant portions from snake venom metalloproteinases (SVMPs) and bradykinin-potentiating-like peptides, which may explain their severe clinical effects during envenomations.
- Comparative analysis shows that Brazilian pit vipers share identical venom proteins among themselves but differ from a related Peruvian subspecies, suggesting possible hybridization, though more extensive sampling is needed to confirm this.
Article Synopsis
- The study evaluated the effectiveness of two specific antivenoms (Uzbiopharm® and Microgen®) against the venom from the Dagestan blunt-nosed viper using advanced methods like venomics and neutralization assays.
- Despite having low concentrations of specific antibodies against venom toxins, both antivenoms were able to neutralize key toxic effects in mice, such as lethality and hemorrhaging.
- The findings highlight the potential for these antivenoms to treat envenomings from Eurasian snakes and emphasize the importance of understanding their specificity for effective use.
Venomics and antivenomics of the poorly studied Brazil's lancehead, (Hoge, 1954), from the Brazilian State of Pará.
J Venom Anim Toxins Incl Trop Dis
April 2020
Background: The Brazil's lancehead, , is a poorly studied pit viper distributed in lowlands of the equatorial rainforests of southern Colombia, northeastern Peru, eastern Ecuador, southern and southeastern Venezuela, Guyana, Suriname, French Guiana, Brazil, and northern Bolivia. Few studies have been reported on toxins isolated from venom of Ecuadorian and Brazilian . The aim of the present study was to elucidate the qualitative and quantitative protein composition of venom from Pará (Brazil), and to carry out a comparative antivenomics assessment of the immunoreactivity of the Brazilian antibothropic pentavalent antivenom [ (SAB) in Portuguese] against the venoms of and reference species, .
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