Publications by authors named "S Querol"
Background: Umbilical cord blood (CB) units stored in banks are an important source of hematopoietic stem cells for transplantation and other cell therapies. New applications, such as their use in transfusions, require rapid quality release as cord blood red blood cells (CB-RBC) have a shorter shelf life.
Study Design And Methods: This project aims to investigate the most prevalent microbial contaminants in CB preparations and validate a rapid sterility testing strategy for CB-RBC based on an automated system (BACT/ALERT®) in tandem with a molecular assay (real-time PCR) capable of detecting at least 100 CFU/mL of Cutibacterium acnes in CB-RBC to accelerate the detection of the most common slow-growing bacteria.
The use of allogeneic induced pluripotent stem cell (iPSC)-derived cell therapies for regenerative medicine offers an affordable and realistic alternative to producing individual iPSC lines for each patient in need. Human Leukocyte Antigens (HLA)-homozygous iPSCs matched in hemi-similarity could provide cell therapies with reduced immune rejection covering a wide range of the population with a few iPSC lines. Several banks of HLA-homozygous iPSCs (haplobanks) have been established worldwide or are underway, to provide clinical grade starting material for cell therapies covering the most frequent HLA haplotypes for certain populations.
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- Some people are trying to figure out if waiting to cut the umbilical cord affects how much useful blood can be collected for banking.
- The study looked at data from hospitals in Spain where babies were born normally and compared how much blood was collected based on waiting 30 seconds, 60 seconds, or more than 120 seconds before clamping the cord.
- They found that while waiting longer means you get less blood overall, the important parts of the blood still remained good, so all the waiting times still work for storing the blood for later use.
Article Synopsis
- Prematurity can cause health problems in newborns, and anemia is a common issue for very premature babies who often need blood transfusions.
- Researchers are looking into using cord blood (from the umbilical cord) as an alternative to adult blood for these transfusions to avoid complications.
- The study compared the quality and characteristics of cord blood red blood cells to adult red blood cells during storage and found that cord blood cells had some stability issues but were generally acceptable for use.