Endoscopic removal of an esophageal bezoar in a patient with jackhammer esophagus.

Esophageal bezoars are known to be significantly rarer compared to gastric bezoars. A 68-year-old woman presented with acute chest pain and worsening dysphagia to both solids and liquids, culminating in inability to consume water without vomiting.

Acute kidney injury after non-cardiac major surgery: has it reduced?

Background: It remains unclear whether the incidence of post-operative acute kidney injury (PO-AKI) has been reduced despite the recent emphasis on its early recognition and prevention in clinical practice. We aimed to investigate the trend in the incidence of PO-AKI and to identify the associated factors affecting its changes.

Methods: We gathered clinical data from patients who underwent non-cardiac major surgeries at three referral hospitals from 2005 to 2020.

Purple corn extract improves benign prostatic hyperplasia by inhibiting 5 alpha-reductase type 2 and inflammation in testosterone propionate-induced rats.

Benign prostatic hyperplasia (BPH) is a health issue caused by an enlarged prostate in older men. Its prevalence increases with age, and it results in urination-related problems. This works studied the effect of purple corn extract (PCE) on improving BPH symptoms using a testosterone propionate (TP)-induced rat model.

Mitoxantrone inhibits and downregulates ER through binding at the DBD-LBD interface.

Targeting the estrogen receptor (ER or ERα) through competitive antagonists, receptor downregulators, or estrogen synthesis inhibition remains the primary therapeutic strategy for luminal breast cancer. We have identified a novel mechanism of ER inhibition by targeting the critical interface between its DNA-binding domain (DBD) and ligand-binding domain (LBD). We demonstrate that mitoxantrone (MTO), a topoisomerase II inhibitor, binds at this previously unexplored DBD-LBD interface.

Electrical Contacts to Graphene by Postgrowth Patterning of Cu Foil for the Low-Cost Scalable Production of Graphene-Based Flexible Electronics.

Numerous studies have focused on graphene owing to its potential as a next-generation electronic material, considering its high conductivity, transparency, superior mechanical stiffness, and flexibility. However, cost-effective mass production of graphene-based electronics based on existing fabrication methods, such as graphene transfer and metal formation, remains a challenge. This study proposes a simple and efficient method for creating electrical contacts with graphene.