Publications by authors named "S Purcell"
Article Synopsis
- * This study is the first large-scale analysis examining the relationship between EDS and genetic variations related to OSA severity, using data from over 11,500 samples across diverse populations.
- * Researchers identified 16 genetic targets linked to EDS and OSA, with eight being new discoveries, and discussed potential therapeutic implications involving insulin resistance and nutritional factors for patients with OSA and EDS.
The establishment of reference intervals for the ClotPro thromboelastometry device in healthy dogs.
J Vet Emerg Crit Care (San Antonio)
December 2024
Objective: To establish reference intervals using a new point-of-care thromboelastometry device in dogs for the extrinsically activated test (EX-test), intrinsically activated test (IN-test), fibrin polymerization test (FIB-test), ecarin test (ECA-test), and tissue plasminogen activator test (TPA-test) and to investigate the effects of storage time on the results.
Design: Prospective clinical study in 2022.
Setting: University teaching hospital.
Background And Objective: In-vitro fertilization (IVF) with intracytoplasmic sperm injection (ICSI) has become increasingly prevalent even in cases without significant male factor infertility; however, stagnant live-birth rates, both nationally and internationally, have driven more research into sperm selection. To date, nothing has replaced swim-up and density-gradient preparation methods and therefore we sought to review the state of the science.
Methods: A PubMed search was performed between years of 1989 and 2024 for English research articles reporting data on sperm selection technology in assisted reproductive technology.
Article Synopsis
- Individuals with schizophrenia (SCZ) show altered sleep patterns, particularly in NREM sleep, with group-level differences seen in EEG metrics like spindles and slow oscillations compared to controls.
- A study involving 103 SCZ patients and 68 controls confirmed these differences and revealed significant variability in sleep metrics among SCZ patients, suggesting individual differences beyond clinical factors are present.
- The research indicated that medication regimens, especially olanzapine, significantly contribute to this variability and highlighted exaggerated age-related effects on certain sleep metrics in SCZ patients, raising concerns about biological aging and potential medication side effects.