Publications by authors named "S Prasad Peri"
Objective: This paper investigated the effects of prenatal drug exposure (PDE), childhood trauma (CT), and their interactions on the neurobiological markers for emotion processing.
Method: Here, in a non-clinical sample of pre-adolescents (9-10 years of age) from the Adolescent Brain Cognitive Development (ABCD) Study (N = 6,146), we investigate the impact of PDE to commonly used substances (ie, alcohol, cigarettes, and marijuana), CT, and their interaction on emotion processing. From the Emotional N-back functional magnetic resonance imaging task data, we selected 26 regions of interests, previously implicated in emotion processing, and conducted separate linear mixed models (108 total) and accounted for available environmental risk factors.
Scale-Up and Postapproval Changes in Orally Inhaled Drug Products: Scientific and Regulatory Considerations.
J Aerosol Med Pulm Drug Deliv
December 2024
Approved drug products may be subject to change(s) for a variety of reasons. The changes may include, but are not limited to, increase in batch size, alteration of the drug product constituent(s), improvement in the manufacturing process, and shift in manufacturing sites. The extent of pharmaceutical testing and the regulatory pathway for timely implementation of any change in the approved product and/or process depends upon the nature and extent of change.
View Article and Find Full Text PDFTo quantify how the viscosities of silicone oil (SO) and liquid metal (LM) relate to emulsion-formation (LM-in-SO SO-in-LM), a process was developed to produce LM pastes with adjustable viscosity and minimal oxide and bubbles. Increased LM viscosity allows greater silicone oil intake and/or intake of higher-viscosity silicone oils.
View Article and Find Full Text PDFArticle Synopsis
- * The study proposed an innovative approach by integrating a specialized surface for better cell attachment, a FUCCI(CA)2 sensor, automated image analysis, and a custom machine learning algorithm, allowing accurate measurement of cell cycle phases in non-adherent cells.
- * The developed automated cell cycle analysis system was validated on leukemia cell lines and is compatible with both non-adherent and adherent cells, making it a valuable free tool for enhancing cancer research and drug development.
Article Synopsis
- Long-term factor Xa (FXa) inhibition shows promise in reducing inflammation and improving outcomes after heart attacks and strokes by impacting platelet function.
- In experiments with mice, chronic FXa inhibition led to smaller brain and heart injury sizes and better cardiac function compared to acute inhibition.
- Analysis of patients revealed that those receiving FXa inhibitors had reduced infarct sizes and showed changes in platelet proteins that suggest decreased release of substances that promote inflammation and clotting.