Publications by authors named "S Prabhakar"

University students are typically highly sedentary, which is associated with adverse physical and mental health outcomes. Attempts to understand university students' sedentary behaviour have typically focused on on-campus teaching and learning activities. While such research has documented that students perceive studying as one of the main barriers to reducing sedentary behaviour, there is little understanding of how and why studying incurs sitting, especially during home-based studying.

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Alternative splicing contributes to complex traits, but whether this differs in trait-relevant cell types across diverse genetic ancestries is unclear. Here we describe cell-type-specific, sex-biased and ancestry-biased alternative splicing in ~1 M peripheral blood mononuclear cells from 474 healthy donors from the Asian Immune Diversity Atlas. We identify widespread sex-biased and ancestry-biased differential splicing, most of which is cell-type-specific.

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Article Synopsis
  • Natural killer (NK) cells are crucial for combating myeloid malignancies, and their function is linked to extended remission in chronic myeloid leukemia (CML), but they experience suppression during the disease.
  • Research using a CML mouse model revealed that NK cells have reduced numbers, an immature state, and decreased ability to kill cancer cells, which can improve when the BCR::ABL1 protein is inhibited.
  • The study found that inflammatory signals in the CML environment, particularly from TNFa, impair NK cell function, indicating that targeting inflammatory pathways could improve NK cell therapies for CML patients.
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The Human Cell Atlas (HCA) is a global partnership "to create comprehensive reference maps of all human cells-the fundamental units of life - as a basis for both understanding human health and diagnosing, monitoring, and treating disease." ( https://www.humancellatlas.

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The development of eco-friendly materials is a challenging one in the research field. Natural fibers are more accessible, biodegradable, inexpensive, and less dense. They offer fewer health risks and are eco-friendly compared to synthetic fibers.

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