Microinvasive oral squamous cell carcinoma: A management protocol.

Microinvasive oral squamous cell carcinoma (MISCC) is the early stage of oral cancer that shows a breach in the basement membrane, and the depth of invasion of the tumour is limited to 0.5-2mm into the papillary stroma. A review of the available data on MISCC was conducted to formulate a management protocol for MISCC and to assess the association of MISCC with oral potentially malignant disorders.

Interbreed variation of dairy cow milk in terms of specific proteome and lipidome for establishing criteria of milk selection.

Background: Ruminant milk is a very complex table food and naturally encrypted with different components possessing various health-promoting characteristics.

Aim: In the present study, we focused on breed-wise compositional difference in milk including various components and release of fatty acids and peptides during digestion.

Methods: First, milk samples were analysed using lactoscan LW milk analyser, MALDI-TOF and gas chromatography.

Synthesis and X-ray evaluation of 7 N-1S thiabendazole based 1,2,3-triazole as a dual metal sensing probe: Molecular logic gate construction, DFT analysis, real water sample analysis and catalytic activity investigation of its metal complexes.

The research aimed to develop of a thiabendazole-derived dual metal sensing probe (TBZT) for the selective detection of metal ions and to explore its metal complexes in reducing environmental pollutants like nitro-phenol and dyes. Absorption and emission based studies predicted the selectivity and sensitivity of TBZT towards Ni(II) and Co(II) ions which was further validated by HNMR, Mass, FT-IR, DFT, Docking, electrochemical, TGA studies and vibrating sample magnetometer analysis techniques. Limit of detection (LOD) values were calculated as 2 × 10 M and 4.

Gene expression analysis reveals mir-29 as a linker regulatory molecule among rheumatoid arthritis, inflammatory bowel disease, and dementia: Insights from systems biology approach.

Background: Rheumatoid arthritis (RA) is a degenerative autoimmune disease, often managed through symptomatic treatment. The co-occurrence of the reported extra-articular comorbidities such as inflammatory bowel disease (IBD), and dementia may complicate the pathology of the disease as well as the treatment strategies. Therefore, in our study, we aim to elucidate the key genes, and regulatory elements implicated in the progression and association of these diseases, thereby highlighting the linked potential therapeutic targets.