Publications by authors named "S Pourbaix"
Introduction: Despite the growing awareness towards the importance of adequate representation of women in clinical trials among patients treated with percutaneous coronary intervention (PCI), available evidence continues to demonstrate a skewed distribution of study populations in favour of men.
Methods And Results: In this pre-specified analysis from the MASTER DAPT screening log and trial, we aimed to investigate the existence of a negative selection bias for women inclusion in a randomized clinical trial. A total of 2847 consecutive patients who underwent coronary revascularization across 65 participating sites, during a median of 14 days, were entered in the screening log, including 1749 (61.
Article Synopsis
- The study aimed to evaluate the prevalence of high bleeding risk (HBR) characteristics in patients who underwent percutaneous coronary intervention (PCI) and assess the representativeness of the MASTER DAPT trial data.
- Out of 2,847 patients screened, 38.6% were identified as HBR, but only 9.9% consented to participate in the trial, revealing differences in HBR characteristics between consenting and non-consenting patients.
- The findings highlight significant selection biases, as the characteristics of HBR patients in the trial differed notably from those in the overall patient population, indicating that trial results may not fully reflect real-world scenarios.
Article Synopsis
- - The study evaluated the effectiveness of abbreviated dual antiplatelet therapy (DAPT) in patients at high bleeding risk undergoing heart procedures, finding that it reduces bleeding without increasing ischemic events.
- - Data from a trial involving 4,579 patients, including 30.7% women, showed that abbreviated DAPT outcomes for major adverse events and bleeding were similar for both sexes.
- - The analysis demonstrated consistent safety and effectiveness of abbreviated DAPT across genders, indicating no significant difference in net adverse clinical events between men and women.
Aims: The current study assessed the impact of COVID-19-related public containment measures (i.e. lockdown) on the ST elevation myocardial infarction (STEMI) epidemic in Belgium.
View Article and Find Full Text PDFVulnerability to cardiac arrest in patients with ST elevation myocardial infarction: Is it time or patient dependent? Results from a nationwide observational study.
Eur Heart J Acute Cardiovasc Care
November 2020
Aim: Cardiac arrest is a common complication of ST elevation myocardial infarction and is associated with high mortality. We evaluated whether vulnerability to cardiac arrest follows a circadian rhythm and whether it is related to specific patient characteristics.
Methods: A total of 24,164 ST elevation myocardial infarction patients who were admitted to 60 Belgian hospitals between 2008-2017 were analysed.