Inflammatory Waldenström Macroglobulinemia is associated with clonal hematopoiesis: a multicentric cohort.

Inflammation in Waldenström Macroglobulinemia (iWM) predicts outcomes after immuno-chemotherapy and BTK inhibitors, but its origin is unknown. Here, we unravel increased clonal hematopoiesis in iWM patients (61% versus 23% in non-inflammatory WM), suggesting a contribution of environmental cells to iWM.

Towards high-power MOPA architectures in single-mode fibers for mid-IR mode-locked operation.

We report on a master oscillator power amplifier (MOPA) system at 2.8 µm to achieve an average power of 10.28 W with a pulse energy and peak power of 403 nJ and 5.

Six-year follow-up of phase II study exploring chemo-free treatment association with idelalisib and obinutuzumab in symptomatic relapsed/ refractory patients with Waldenström's macroglobulinemia.

We present the 6-year update of a phase 2 study evaluating the combination of obinutuzumab and idelalisib in relapse/refractory Waldenstrom macroglobulinemia. The results of the REMODEL trial demonstrated interesting efficacy in a high-risk genotype profile population. The primary endpoint was achieved with a median PFS of 25.

2.8-µm polarization-maintaining Er fiber laser mode-locked by a GaSb-based SESAM.

A GaSb-based SEmiconductor Saturable Absorber Mirror (SESAM) enables continuous-wave picosecond mode-locked operation with excellent stability of a polarization-maintaining mid-infrared Er:ZBLAN fiber laser. The GaSb-based SESAM mode-locked fiber laser delivers an average output power of 190 mW at 2.76 µm at a repetition rate of 32.

Mid-infrared interferometry with non-adiabatic tapered ZBLAN optical fiber.

This work illustrates, to the best of our knowledge, the first non-adiabatic tapered single-mode zirconium fluoride optical fiber sensor in the mid-infrared spectral range. It is designed and fabricated via pulling and heating technique. A waist diameter d = 25 µm with no visible crystallization is achieved, overcoming the typical fluoride glass challenges associated with crystallization, narrow temperature fabrication window, and low glass transition temperature.