Publications by authors named "S Poser"
Parkinson's disease (PD) is a neurodegenerative disorder caused by complex genetic and environmental factors. Genome-edited human pluripotent stem cells (hPSCs) offer the uniique potential to advance our understanding of PD etiology by providing disease-relevant cell-types carrying patient mutations along with isogenic control cells. To facilitate this experimental approach, we generated a collection of 55 cell lines genetically engineered to harbor mutations in genes associated with monogenic PD ( A53T, A30P, Ex3del, Q129X, Ex1-5del, G2019S, FS, R498X/FS, c.
View Article and Find Full Text PDFNational Update on Measles Cases and Outbreaks - United States, January 1-October 1, 2019.
MMWR Morb Mortal Wkly Rep
October 2019
Article Synopsis
- * The majority of cases (93%) were linked to the 22 outbreaks, with 89% occurring in unvaccinated individuals, highlighting the risk of outbreaks from international travelers to unvaccinated populations.
- * Major outbreaks in Orthodox Jewish communities in New York accounted for 75% of cases, necessitating strong public health responses and ongoing collaboration to maintain high vaccination rates and prevent further transmission.
Cancer cells can switch between signaling pathways to regulate growth under different conditions. In the tumor microenvironment, this likely helps them evade therapies that target specific pathways. We must identify all possible states and utilize them in drug screening programs.
View Article and Find Full Text PDF