Antimycobacterial evaluation of novel hybrid arylidene thiazolidine-2,4-diones.

A series of novel hybrid heterocycles comprising arylidene thiazolidine-2,4-dione and 1-cyclopropyl-2-(2-fluorophenyl)ethanone were synthesized. These compounds were evaluated for their antimycobacterial activity against Mycobacterium tuberculosis H37Rv in High Throughput Screen. Most of the hybrid arylidene thiazolidine-2,4-diones displayed moderate to good activity with MIC of less than 50 μM.

3-[2-Cyclo-propyl-1-(2-fluoro-phen-yl)-2-oxoeth-yl]-5-(4-methyl-sulfanyl-benzyl-idene)-1,3-thia-zolidine-2,4-dione.

In the title compound, C(22)H(18)FNO(3)S(2), the five-membered thia-zolidine ring is planar (r.m.s.