Publications by authors named "S Ponnampalavanar"
: The emergence and dissemination of carbapenem-resistant organisms, particularly and , pose a significant threat to healthcare systems worldwide. This retrospective study aims to characterise carbapenem-resistant (CRAB) and carbapenem-resistant (CRKP) strains in a teaching hospital and to determine the risk factors associated with patients' in-hospital mortality. : A total of 90 CRAB and 63 CRKP were included in this study.
View Article and Find Full Text PDFAssessment of antimicrobial prescribing patterns, guidelines compliance, and appropriateness of antimicrobial prescribing in surgical-practice units: point prevalence survey in Malaysian teaching hospitals.
Front Pharmacol
April 2024
Article Synopsis
- * Out of 566 surgical inpatients, 44.2% received antimicrobial treatment, with significant issues including non-compliance and inappropriate prescribing identified, particularly with incorrect duration and unnecessary broad-spectrum use.
- * The findings suggest a need for improved antimicrobial stewardship focused on enhancing surgical prophylaxis practices, promoting proper documentation, and raising awareness among healthcare providers.
Combining the advantages of PCR and LAMP, we described a new technique, namely PCR-LAMP, for malaria diagnosis. The whole process of DNA amplification can be completed in 35 min. This hybrid amplification technique markedly improved the sensitivity of detection compared to the classic single PCR or LAMP assay alone.
View Article and Find Full Text PDFThe COVID-19 pandemic led to an initial increase in the incidence of carbapenem-resistant Enterobacterales (CRE) from clinical cultures in South-East Asia hospitals, which was unsustained as the pandemic progressed. Conversely, there was a decrease in CRE incidence from surveillance cultures and overall combined incidence. Further studies are needed for future pandemic preparedness.
View Article and Find Full Text PDFBackground: The high burden of extended-spectrum beta-lactamase-producing (ESBL)-producing Enterobacterales worldwide, especially in the densely populated South East Asia poses a significant threat to the global transmission of antibiotic resistance. Molecular surveillance of ESBL-producing pathogens in this region is vital for understanding the local epidemiology, informing treatment choices, and addressing the regional and global implications of antibiotic resistance.
Methods: Therefore, an inventory surveillance of the ESBL- (ESBL-EC) isolates responsible for infections in Malaysian hospitals was conducted.