Publications by authors named "S Polychronis"
Article Synopsis
- Drooling in Parkinson's disease (PD) is characterized by an excess of saliva in the mouth, but the exact cause is not fully understood.
- *It has been linked to more severe non-motor symptoms like cognitive issues, sleep problems, and autonomic dysfunction, as well as worse motor symptoms.
- *The presence of drooling in PD patients is related to various factors, including impaired neural pathways, rather than a single cause.
Background: Dysfunction of mitochondrial energy generation may contribute to neurodegeneration, leading to synaptic loss in Parkinson's disease (PD). The objective of this study was to find cross-sectional and longitudinal changes in PET markers of synaptic vesicle protein 2A, sigma 1 receptor, and mitochondrial complex 1 in drug-naive PD patients.
Methods: Twelve early drug-naive PD patients and 16 healthy controls underwent a 3-Tesla MRI and PET imaging to quantify volume of distribution of [ C]UCB-J, [ C]SA-4503, and [ F]BCPP-EF for synaptic vesicle protein 2A, sigma 1 receptor, and mitochondrial complex 1, respectively.
Predict cognitive decline with clinical markers in Parkinson's disease (PRECODE-1).
J Neural Transm (Vienna)
January 2020
Over the course of the disease, about 80% of Parkinson's disease patients will develop cognitive impairment. However, predictive factors associated with cognitive decline are still under investigation. Here, we investigated which clinically available markers are predictive of cognitive impairment in a cohort of early drug-naïve Parkinson's disease patients.
View Article and Find Full Text PDF[F]Florbetapir PET/MR imaging to assess demyelination in multiple sclerosis.
Eur J Nucl Med Mol Imaging
February 2020
Purpose: We evaluated myelin changes throughout the central nervous system in Multiple Sclerosis (MS) patients by using hybrid [F]florbetapir PET-MR imaging.
Methods: We included 18 relapsing-remitting MS patients and 12 healthy controls. Each subject performed a hybrid [F]florbetapir PET-MR and both a clinical and cognitive assessment.