Publications by authors named "S Pollichieni"
Article Synopsis
- In Italy, the demand for stem cell transplants is higher than the number of available donors, prompting a study on the public's knowledge and attitudes towards stem cell donation.* -
- An online survey was conducted with 1518 participants, revealing that non-donors had significantly less knowledge about donation (51.7% vs 24.4%) and expressed negative feelings like fear and confusion.* -
- The study found that better knowledge correlates with increased willingness to donate, and suggests there is a need for improved awareness strategies around stem cell donation in Italy.*
Article Synopsis
- - The Italian Society for Immunogenetics and Transplantation Biology (AIBT) established a working group to create recommendations for histocompatibility testing prior to allogeneic hematopoietic stem cell transplantation (HSCT), emphasizing the critical role of HLA compatibility between donors and recipients.
- - AIBT's comprehensive recommendations include guidelines on HLA typing, definitions of histocompatibility, the significance of anti-HLA antibodies, and the role of NK alloreactivity, aimed at improving the quality of HSCT care.
- - With the rise of HLA-mismatched transplants, the document is designed to assist healthcare workers in optimizing resources and fostering collaboration with transplant physicians for better patient outcomes.
Introduction: Soon after the onset of the SARS-CoV-2 pandemic, viral screening by nasopharyngeal swab became mandatory for allogeneic hematopoietic stem cell (HSC) donor eligibility.
Methods: We described our monocenter experience with allogeneic HSC donors from February 1 to the October 31, 2020 to verify whether the introduction of SARS-CoV-2 screening altered the donor eligibility and/or entailed a prolongation of the evaluation process.
Results: A total of 21 allogeneic HSC donors were screened during the above-mentioned period upon request by the local transplant physicians or by the Italian Bone Marrow Donor Registry; among the HSC donors ( = 17) who completed the eligibility process and further received the nasopharyngeal swab, all but one were negative for the presence of SARS-CoV-2.
In Italy, an HLA-matched unrelated donor is currently the primary donor when a HLA matched sibling is not found for allogeneic haematopoietic stem cell transplantation (HSCT). Better outcomes for transplantation require optimal matching between donor and recipient at least at the HLA-A, -B, -C, and -DRB1 loci; therefore, the availability of HLA-matched unrelated donors is important. The enormous HLA polymorphism has always necessitated registries with a large number of individuals in order to be able to provide well-matched donors to a substantial percentage of patients.
View Article and Find Full Text PDFAllelic HLA Matching and Pair Origin Are Favorable Prognostic Factors for Unrelated Hematopoietic Stem Cell Transplantation in Neoplastic Hematologic Diseases: An Italian Analysis by the Gruppo Italiano Trapianto di Cellule Staminali e Terapie Cellulari, Italian Bone Marrow Donor Registry, and Associazione Italiana di Immunogenetica e Biologia dei Trapianti.
Transplant Cell Ther
May 2021
HLA molecules are important for immunoreactivity in allogeneic hematopoietic stem cell transplantation (HSCT). The Gruppo Italiano Trapianto di Cellule Staminali e Terapie Cellulari, Italian Bone Marrow Donor Registry, and Associazione Italiana di Immunogenetica e Biologia dei Trapianti promoted a retrospective observational study to evaluate HLA matching and the impact of allelic HLA mismatching and non-HLA factors on unrelated Italian HSCT outcomes. From 2012 to 2015, 1788 patients were enrolled in the study.
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