Publications by authors named "S Plaza-Garcia"
Bladder cancer treatment via intravesical drug administration achieves reasonable survival rates but suffers from low therapeutic efficacy. To address the latter, self-propelled nanoparticles or nanobots have been proposed, taking advantage of their enhanced diffusion and mixing capabilities in urine when compared with conventional drugs or passive nanoparticles. However, the translational capabilities of nanobots in treating bladder cancer are underexplored.
View Article and Find Full Text PDFHyperglycemia has been linked to worsening outcomes after subarachnoid hemorrhage (SAH). Nevertheless, the mechanisms involved in the pathogenesis of SAH have been scarcely evaluated so far. The role of hyperglycemia was assessed in an experimental model of SAH by T weighted, dynamic contrast-enhanced magnetic resonance imaging (TW and DCE-MRI), [F]BR-351 PET imaging and immunohistochemistry.
View Article and Find Full Text PDFArticle Synopsis
- - Atherosclerosis is a serious disease that can lead to heart attacks and strokes, but diagnosing vulnerable plaques is difficult because current methods lack accuracy and specificity.
- - New technologies are being developed using customized nanoparticles for noninvasive imaging of atherosclerotic plaques, which can improve diagnosis and prediction of plaque rupture risk.
- - Our research focuses on comparing the imaging effectiveness of different nanoparticles, demonstrating that Gd (III)-doped amorphous calcium carbonate nanoparticles are promising for targeted imaging of atherosclerosis, particularly when functionalized with specific ligands for targeting calcifications and inflammation.
Therapeutic effect of 7 nicotinic receptor activation after ischemic stroke in rats.
J Cereb Blood Flow Metab
August 2023
Nicotinic acetylcholine α7 receptors (α7 nAChRs) have a well-known modulator effect in neuroinflammation. Yet, the therapeutical effect of α7 nAChRs activation after stroke has been scarcely evaluated to date. The role of α7 nAChRs activation with PHA 568487 on inflammation after brain ischemia was assessed with positron emission tomography (PET) using [F]DPA-714 and [F]BR-351 radiotracers after transient middle cerebral artery occlusion (MCAO) in rats.
View Article and Find Full Text PDFManganese ferrite nanoparticles display interesting features in bioimaging and catalytic therapies. They have been recently used in theranostics as contrast agents in magnetic resonance imaging (MRI), and as catalase-mimicking nanozymes for hypoxia alleviation. These promising applications encourage the development of novel synthetic procedures to enhance the bioimaging and catalytic properties of these nanomaterials simultaneously.
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