Publications by authors named "S Pizzamiglio"
Article Synopsis
- The study addresses the growing concern of cardiovascular diseases (CVDs) among adolescent and young adult (AYA) survivors of breast cancer due to the cardiotoxic effects of cancer treatments.
- Researchers developed a Bayesian network model using data from over a thousand young female BC survivors to predict CVD risk, achieving strong classification performance and clear causal relationships.
- An application was created to provide individual risk assessments for patients, aimed at helping clinicians personalize follow-up care for AYA BC survivors at higher risk of developing CVDs.
Background: Ductal carcinoma in situ (DCIS) is the most common form of preinvasive breast cancer, with 5-10% of cases progressing into invasive disease. Herein, we investigated the association between HER2-low and clinico-pathological characteristics in DCIS and subsequent ipsilateral loco-regional relapse (LRR).
Materials And Methods: We accessed our prospectively maintained institutional database.
Purpose: The relevance of cardiotoxicity in the context of HER2-positive breast cancer is likely to increase with increasing patient treatment exposure, number of treatment lines, and prolonged survival. Circulating biomarkers to early identify patients at risk of cardiotoxicity could allow personalized treatment and follow-up measures. The aim of this study is to examine the relationship between circulating microRNAs and adverse cardiac events in HER2-positive breast cancer patients.
View Article and Find Full Text PDFArticle Synopsis
- Clinical trials classify HER2-low breast cancer using IHC scores of 1+ or 2+ without gene amplification, but daily practice sees variability in accuracy due to differences among observers.
- This study aimed to identify HER2-low tumors using gene expression profiling, analyzing data from multiple datasets to establish a consistent HER2-low signature.
- The HER2-low signature effectively distinguished between IHC categories and showed significant enrichment for pathways related to lipid metabolism, immune response, and other functions, confirming its reliability across different datasets.
Neoadjuvant Chemotherapy in High-Grade Myxoid Liposarcoma: Results of the Expanded Cohort of a Randomized Trial From Italian (ISG), Spanish (GEIS), French (FSG), and Polish Sarcoma Groups (PSG).
J Clin Oncol
March 2024
Purpose: A randomized trial was conducted to compare neoadjuvant standard (S) anthracycline + ifosfamide (AI) regimen with histology-tailored (HT) regimen in selected localized high-risk soft tissue sarcoma (STS). The results of the trial demonstrated the superiority of S in all STS histologies except for high-grade myxoid liposarcoma (HG-MLPS) where S and HT appeared to be equivalent. To further evaluate the noninferiority of HT compared with S, the HG-MLPS cohort was expanded.
View Article and Find Full Text PDF