Publications by authors named "S Pirruccello"
Comparative antiplatelet effects of chlorthalidone and hydrochlorothiazide.
J Clin Hypertens (Greenwich)
October 2022
Chlorthalidone (CTD) may be superior to hydrochlorothiazide (HCTZ) in the reduction of adverse cardiovascular events in hypertensive patients. The mechanism of the potential benefit of CTD could be related to antiplatelet effects. The objective of this study was to determine if CTD or HCTZ have antiplatelet effects.
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- A 2-year-old girl was diagnosed with natural killer cell acute lymphoblastic leukemia and initially treated with a standard chemotherapy regimen.
- Two months later, her leukemia relapsed with different characteristics, prompting a switch to acute myeloid leukemia therapy and an unrelated donor stem cell transplant.
- A detailed analysis of her initial diagnostic specimen revealed minimal myeloperoxidase expression, which was previously missed, highlighting the importance of recognizing low levels of this marker in leukemia classification.
Background: The use of immunodeficient mice transplanted with human hematopoietic stem cells is an accepted approach to study human-specific infectious diseases such as HIV-1 and to investigate multiple aspects of human immune system development. However, mouse and human are different in sialylation patterns of proteins due to evolutionary mutations of the CMP-N-acetylneuraminic acid hydroxylase (CMAH) gene that prevent formation of N-glycolylneuraminic acid from N-acetylneuraminic acid. How changes in the mouse glycoproteins' chemistry affect phenotype and function of transplanted human hematopoietic stem cells and mature human immune cells in the course of HIV-1 infection are not known.
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