Publications by authors named "S Pinel"

Article Synopsis
  • The study investigated the inflammatory responses in patients undergoing transcatheter aortic valve implantation (TAVI) using low radial force valves versus high radial force valves.
  • It found that patients with low radial force valves had significantly lower levels of high-sensitivity C-reactive protein (hsCRP) after the procedure, indicating less inflammation.
  • Additionally, these patients experienced fewer occurrences of new left bundle branch block (LBBB), suggesting that lower inflammation might reduce the risk of heart conduction issues.
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Due to the start of the monkeypox epidemic in 2022, we retrospectively analyzed the adverse drug reactions (ADRs) reported in France after monkeypox vaccinations with the third-generation smallpox vaccine. Ninety-eight cases, representing 172 ADRs, were reported. ADRs were mostly expected reactogenicity reactions occurring within days after the first dose of vaccine and having a quick favorable outcome.

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Aim: To describe the symptoms, patient demographics, and trends over time of adverse drug reactions (ADRs) related to weak opioid analgesics reported to the French vigilance networks.

Methods: Retrospective study of data from French Poison Control Centers and Pharmacovigilance Centers databases of weak opioid analgesics-related ADRs cases, with high causality score, in adults, in therapeutic analgesic use, without co-exposure, between 2011 and 2020.

Results: The number of cases was 388 in the Poisonings database and 155 in the Pharmacovigilance database; ratio of the number of these cases to all reported cases during the study period was 0.

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Article Synopsis
  • Patients with heart failure (HF) showed a temporary increase in eosinophil counts after receiving anakinra, which is an interleukin-1 blocker.
  • The study involved 64 HF patients, with measurements taken before and after treatment, and showed significant changes in eosinophil levels correlating with cardiorespiratory fitness (CRF).
  • Higher eosinophil levels were noted in patients experiencing injection site reactions, and these patients also showed greater improvements in their peak oxygen consumption during exercise tests.
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