Publications by authors named "S Pinar Kara"
Alzheimer's disease is a chronic complex neurodegenerative disease characterized with amyloid plaques and loss of neurons. TGF-β1 is important growth factor, plays critical roles in cell metabolism, tissue homeostasis, neuronal development, and synaptic plasticity. In this study, we aimed to examine the effect of TGF-β1 on the regulation of α, β, and γ-secretase enzymes, Aβ-40 accumulation, apoptosis, and neuronal damage in an experimental Scopolamine-induced AD-like model.
View Article and Find Full Text PDFDeep eutectic solvents (DESs) have emerged as promising solvents for biocatalysis. While their impact on enzyme solvation and stabilization has been studied for several enzyme classes, their role in substrate binding is yet to be investigated. Herein, molecular dynamics (MD) simulations of horse-liver alcohol dehydrogenase (HLADH) are performed in choline chloride-ethylene glycol (ChCl-EG) and choline chloride-glycerol (ChCl-Gly) at varying water concentrations.
View Article and Find Full Text PDFLung cancer in patients with pulmonary fibrosis: characteristics features and prognosis.
Sarcoidosis Vasc Diffuse Lung Dis
December 2024
Article Synopsis
- Lung cancer is a significant issue for patients with Idiopathic Pulmonary Fibrosis (IPF), but there is limited research on those with non-IPF Pulmonary Fibrosis (PF); this study compares the two groups in terms of characteristics and survival.
- The study analyzed data from 251 patients diagnosed with lung cancer between 2010 and 2022, finding that most were elderly men with a high smoking rate, and differing patterns of lung imaging between the two groups.
- Both IPF-LC and non-IPF PF-LC patients had high 5-year mortality rates around 64%, with the shortest survival noted in non-IPF PF patients with unclassified PF.
Article Synopsis
- - A study was conducted on 240 pregnant women (120 with pregestational diabetes) to examine changes in systemic inflammatory indices and APRI scores during pregnancy, and their association with perinatal outcomes.
- - Results indicated significant alterations in inflammatory markers across trimesters, with notable cut-off values identified for predicting low birth weight and preterm delivery based on certain indices.
- - The findings suggest that monitoring the NLR in the first trimester and the APRI score in the last trimester could help predict perinatal outcomes in pregnancies complicated by pregestational diabetes.
Redox biocatalysis is an essential pillar of the chemical industry. Yet, the enzymes' nature restricts most reactions to aqueous conditions, where the limited substrate solubility leads to unsustainable diluted biotranformations. Non-aqueous media represent a strategic solution to conduct intensified biocatalytic routes.
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