A metabolic atlas of mouse aging.

Humans are living longer, but this is accompanied by an increased incidence of age-related chronic diseases. Many of these diseases are influenced by age-associated metabolic dysregulation, but how metabolism changes in multiple organs during aging in males and females is not known. Answering this could reveal new mechanisms of aging and age-targeted therapeutics.

Powdered silk: A promising biopolymer for the treatment of dye contaminated water.

Discharge of textile dye effluents into water bodies is creating stress to aquatic life and contaminating water resources. In this study, a new biopolymer adsorbent silk fibroin (SF) was prepared from Bombyx mori silk fibroin (SF) and used for removal of Solochrome Black-T (SB-T) from water. This innovative adsorbent exhibits an exceptional adsorption capacity of 20.

The aging tumor metabolic microenvironment.

Despite the higher incidence of cancer with increasing age, few preclinical or clinical studies incorporate age. This, coupled with an aging world population, requires that we improve our understanding of how aging affects cancer development, progression, and treatment. One key area will be how the tumor microenvironment (TME) changes with age.

Loss of attachment promotes proline accumulation and excretion in cancer cells.

Previous studies have revealed a role for proline metabolism in supporting cancer development and metastasis. In this study, we show that many cancer cells respond to loss of attachment by accumulating and secreting proline. Detached cells display reduced proliferation accompanied by a general decrease in overall protein production and de novo amino acid synthesis compared to attached cells.