Publications by authors named "S Pignalosa"
Background: Novel circulating markers for the non-invasive staging of chronic liver disease (CLD) are in high demand. Although underutilized, extracellular matrix (ECM) components offer significant diagnostic potential. This study evaluates ECM-related markers in hepatitis C virus (HCV)-positive patients across varying fibrosis stages.
View Article and Find Full Text PDFChronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an immune-mediated disorder affecting the peripheral nervous system. Despite the established diagnostic criteria, monitoring disease activity and treatment remains challenging. To address this limitation, we investigated serum neurofilament light chain (sNfL) and serum free light chains (sFLCs) as potential biomarkers.
View Article and Find Full Text PDFArticle Synopsis
- The immune response involving antibodies is driven by immunoglobulins produced by activated B cells, which recognize pathogens and differentiate into plasma cells that secrete antibodies.
- In multiple myeloma, a type of cancer, there is an overproduction of these antibodies due to the excessive growth of plasma cells in the bone marrow, leading to the presence of monoclonal components in the blood and urine that can be used as disease biomarkers.
- The Hevylite assay quantifies both involved and uninvolved immunoglobulins in patients with multiple myeloma, providing critical information for diagnosis, monitoring, and evaluating treatment responses according to international guidelines.
Objectives: To assess serum immunoglobulin G (IgG) subclasses in a cohort of systemic sclerosis (SSc) patients and to evaluate the influence of IgG subclasses in the main complications of the disease.
Methods: The serum level of IgG subclasses was evaluated in 67 SSc patients and 48 healthy controls (HC), matched for sex and age. Serum samples were collected and measured IgG1-4 subclasses by turbidimetry.
We report two cases of SARS-CoV-2 recombinant variant XE detected in nasopharyngeal swabs (NPS) of hospitalized patients with no evident epidemiological link in Lazio, Central Italy. Whole-Genome Sequencing (WGS) performed on an Ion Torrent GSS5 platform according to Italian flash surveys showed genomes corresponding to the PANGOLIN unclassified lineage and the Nextclade XE clade. Further analyses were then carried out to investigate more deeply the genetic characteristics of these XE-like sequences.
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