Publications by authors named "S Picciolini"
Background: Alzheimer's disease (AD) is a neurodegenerative condition for which there is currently no available medication that can stop its progression. Previous studies suggest that mild cognitive impairment (MCI) is a phase that precedes the disease. Therefore, a better understanding of the molecular mechanisms behind MCI conversion to AD is needed.
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- - Microglia and macrophages produce extracellular vesicles (EVs) that can affect the development of myelin lesions, with microglial EVs supporting oligodendrocyte precursor cell (OPC) differentiation, while the effect of macrophage EVs is less clear.
- - Research showed that EVs from macrophages, especially those in an inflammatory state, do not aid OPC differentiation and actually inhibit it, but their lipid content can still promote OPC maturation similar to microglial EVs.
- - Key promyelinating endocannabinoids (like anandamide) were found in EVs from both cell types, indicating a critical role for these endocannabinoids in OPC maturation and suggesting potential targets for enhancing myelin repair
Article Synopsis
- The 'QuantitatEVs' workshop focused on quantitative methods for analyzing extracellular vesicles (EVs), from large bulk samples to individual vesicles, emphasizing new technologies.
- * The event explored critical issues in analyzing EV-associated molecules and biophysical features, which are key for discovering and validating EV biomarkers for clinical use.
- * Held in Trento, Italy, from January 31 to February 2, 2023, the workshop included a follow-up event in Milan aimed at supporting early career researchers.
Parkinson's disease (PD) is a neurodegenerative disorder affecting about 10 million people worldwide with a prevalence of about 2% in the over-80 population. The disease brings in also a huge annual economic burden, recently estimated by the Michael J Fox Foundation for Parkinson's Research to be USD 52 billion in the United States alone. Currently, no effective cure exists, but available PD medical treatments are based on symptomatic prescriptions that include drugs, surgical approaches and rehabilitation treatment.
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- Heart transplant is the best treatment for severe heart failure, and cardiac rehabilitation can enhance recovery and quality of life for these patients.
- This study will compare traditional cardiac rehab with tele-rehabilitation in patients after heart transplant, involving 40 participants who will be monitored over time for various health metrics.
- Researchers will analyze data to understand the safety and effectiveness of telerehabilitation and identify biological markers that can help customize treatment for individual patients.