Publications by authors named "S Philip Anthony"
Background: The robustness and persistence of vaccine antigen-induced antibodies are often used as proxy indicators of vaccine efficacy, but immune responses to vaccine vectors are typically less well-defined. Our study considered the kinetics of immunoglobulin (IgG) responses against the vector (vesicular stomatitis Indiana virus [VSIV]) nucleoprotein (N) and the inserted antigen (Ebola virus [EBOV]) glycoprotein (GP1,2) components of the rVSVΔG-ZEBOV-GP (rVSV-ZEBOV) vaccine and evaluated their use as biomarkers to confirm self-reported vaccination status.
Methods: From the Partnership for Research on Ebola Virus in Liberia (PREVAIL) I clinical trial (NCT02344407), we randomly selected 212 participants who received rVSV-ZEBOV (n=107) or placebo (n=105).
Purpose: To identify whether the timing of supervised physical rehabilitation initiation after isolated arthroscopic anterior cruciate ligament reconstruction (ACLR) is associated with (1) diagnosis of arthrofibrosis and (2) surgical intervention for arthrofibrosis within 12 months after surgery.
Methods: Outpatient isolated arthroscopic ACLR procedures in 2017-2020 were identified from the Merative MarketScan database. The cohort was limited to patients aged 18 to 64 years who initiated supervised physical rehabilitation at 0 to 30 days postoperatively and had continuous enrollment in the database for 12 months before and after surgery.
Article Synopsis
- - Lassa virus (LASV) leads to hundreds of thousands of infections in Western Africa annually, with about 20% progressing to Lassa fever, a serious disease that has a high fatality rate.
- - Currently, there are no approved vaccines or treatments for Lassa fever, but researchers have been working on recombinant LASVs (rLASVs) that show promising results as vaccines in animal models.
- - The new vaccine candidate, rLASV/IGR-CD, demonstrated high safety and effectiveness in guinea pigs, offering complete protection against lethal LASV exposure and advancing the development of a live-attenuated vaccine for Lassa fever.
Purpose: To characterize the initiation and use of supervised physical rehabilitation after arthroscopic anterior cruciate ligament reconstruction (ACLR), including overall duration of rehabilitation and number of rehabilitation visits, and to describe demographic and clinical predictors of rehabilitation initiation and use characteristics.
Methods: Patients aged 14 to 64 years in the United States who underwent ACLR from 2017 to 2020 were identified using the Merative MarketScan Database. For patients initiating rehabilitation within 45 days postoperatively, the overall duration and number of visits within 1 year after surgery were determined.
Article Synopsis
- The research focused on the role of the human antigen R (HuR) RNA-binding protein in regulating calcium-driven thermogenesis in brown adipocytes, highlighting that its deletion leads to a dysfunction in thermogenesis and a decrease in crucial calcium transport genes.
- The study found that HuR stabilizes the mRNA of ryanodine receptor 2 (RyR2), which is vital for calcium signaling and heat generation; its depletion results in impaired thermogenic response, especially under cold stress.