Circatrigintan hormonal and skin surface temperature rhythms following hysterectomy.

Starting 2.5 weeks after removal of her uterus, but not of her ovaries, a 34-year-old, clinically healthy woman contributed a daily blood sample at 0900 and measured her skin surface temperature on her right breast above the nipple and just below the right breast daily for the ensuing 2 months. In aliquots of serum stored frozen, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) were determined in the United States; these hormones and prolactin, estradiol (E2), progesterone, testosterone, dehydroepiandrosterone-sulfate (DHEA-S), cortisol, triiodothyronine (T3), free thyroxine (T4), and free testosterone were determined in Italy.

Alternative indications for pulsatile gonadotropin-releasing hormone therapy in infertile women.

Three groups of women with different types of ovulatory dysfunction who had failed to conceive on conventional therapy were treated with pulsatile gonadotropin-releasing hormone (GnRH). Group A consisted of nine patients with luteal phase defect; group B included four patients with apparently normal menstrual cycles but disordered folliculogenesis seen by serial ultrasound examinations; and group C consisted of eight patients who exhibited anovulation or irregular ovulation. GnRH was administered subcutaneously or intravenously in dosages varying from 5 micrograms to 20 micrograms, with pulse frequency of 2 to 3 hours in 53 cycles.

Elevated LHRH levels in human milk.

Anterior pituitary gonadotropins are regulated by the hypothalamic peptide hormone LHRH. However, the extrahypothalamic source(s) as well as extrapituitary action(s) of LHRH exist. We describe the discovery of relatively elevated levels of LHRH in human milk and its possible functions in the neonates.