Cancer Neuroscience of Brain Tumors: From Multicellular Networks to Neuroscience-Instructed Cancer Therapies.

Deepening our understanding of neuro-cancer interactions can innovate brain tumor treatment. This mini review unfolds the most relevant and recent insights into the neural mechanisms contributing to brain tumor initiation, progression, and resistance, including synaptic connections between neurons and cancer cells, paracrine neuro-cancer signaling, and cancer cells' intrinsic neural properties. We explain the basic and clinical-translational relevance of these findings, identify unresolved questions and particularly interesting future research avenues, such as central nervous system neuro-immunooncology, and discuss the potential transferability to extracranial cancers.

Biglycan-driven risk stratification in ZFTA-RELA fusion supratentorial ependymomas through transcriptome profiling.

Recent genomic studies have allowed the subdivision of intracranial ependymomas into molecularly distinct groups with highly specific clinical features and outcomes. The majority of supratentorial ependymomas (ST-EPN) harbor ZFTA-RELA fusions which were designated, in general, as an intermediate risk tumor variant. However, molecular prognosticators within ST-EPN ZFTA-RELA have not been determined yet.

Spatial optimization of industrial symbiosis for heat supply of agricultural greenhouses.

Despite the many benefits of greenhouses, it is challenging to meet their heating demand, as greenhouses belong to the most energy-intensive production systems in the agriculture sector. Industrial symbiosis can bring an effective solution by utilizing waste heat from other industries to meet the greenhouse heat demand. This study proposes an optimization framework by which optimum symbiotic relationships can be identified.

Prospective life cycle assessment of cost-effective pathways for achieving the FuelEU Maritime Regulation targets.

To reduce environmental impacts from the shipping industry, the FuelEU Maritime Regulation has set a binding 80 % reduction target for well-to-wake (WTW) greenhouse gas (GHG) emissions by 2050. This article presents a prospective life cycle assessment (LCA) comparing the environmental impacts of e-ammonia, e-methanol, e-Fischer Tropsch (FT) diesel, and e-liquefied natural gas (LNG)-for maritime applications in Europe. In addition to e-fuels, traditional propulsion technologies using very low sulfur fuel oil (VLSFO) and LNG are assessed, both with and without integrating ship-based carbon capture (SBCC) systems.

Clinical characteristics and outcome of central nervous system tumors harboring NTRK gene fusions.

Purpose: TRK fusions are detected in less than 2% of central nervous system tumors. There are limited data on the clinical course of affected patients.

Experimental Design: We conducted an international retrospective cohort study of patients with TRK fusion-driven CNS tumors.