Publications by authors named "S Pfau"
Mayaro virus is endemic to the tropical Americas, where the incidence is currently increasing. Like other viruses of the Semliki Forest virus serocomplex, such as , symptomatic infections are typically characterised by an acute febrile disease followed by long-lasting arthralgia. Cases in travellers are rarely reported but may be underdiagnosed.
View Article and Find Full Text PDFArticle Synopsis
- - The study aimed to investigate the role of serotonin levels in patients experiencing post-acute sequelae of COVID-19 (PASC), a condition affecting 10-20% of those who had the virus, characterized by fatigue and other symptoms.
- - Researchers conducted a case-control study with 34 PASC patients and 14 healthy controls, measuring serum serotonin levels using advanced testing techniques and evaluating patients' ongoing symptoms after infection.
- - Findings revealed no significant difference in serotonin levels between PASC patients and healthy controls, indicating that serotonin is not a reliable biomarker for PASC diagnosis or treatment, specifically cautioning against using serotonin-based therapies.
Article Synopsis
- Around 50% of women referred for invasive coronary angiography experience angina but have nonobstructive coronary arteries, with conditions like vasospastic angina and microvascular dysfunction being key issues.
- In a study from 2018 to 2023 involving 198 women, those who underwent coronary function testing (CFT) were more likely to be diagnosed with vasomotor disorders than those who only had coronary angiography (CA), with significant differences in the types of diagnoses given.
- The results showed that after CFT, there was a higher rate of changes in medications and a more aggressive approach to antianginal therapy compared to just undergoing CA, highlighting the importance of coronary function
The blood-brain barrier (BBB) protects the brain and maintains neuronal homeostasis. BBB properties can vary between brain regions to support regional functions, yet how BBB heterogeneity occurs is poorly understood. Here, we used single-cell and spatial transcriptomics to compare the mouse median eminence, one of the circumventricular organs that has naturally leaky blood vessels, with the cortex.
View Article and Find Full Text PDF