Publications by authors named "S Petry"
Background: People with diabetes benefit from continuous glucose monitoring (CGM) systems. A downside of these valuable aids for diabetes management is the generation of a tremendous amount of waste. This study aimed to quantify this CGM-related waste.
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- Most vertebrate spindles utilize branching microtubule nucleation, where new microtubules form alongside existing ones.
- The study highlights the role of hepatoma up-regulated protein (HURP) in this process, showing it is essential for RanGTP-induced microtubule branching in Xenopus egg extract.
- HURP stabilizes the microtubule structure and shifts its function toward facilitating branching by localizing to TPX2 condensates, which are crucial for spindle assembly, supported by high-resolution cryo-EM imaging of HURP on microtubules.
Microtubules are dynamic filaments that assemble spindles for eukaryotic cell division. As the concentration profiles of soluble tubulin and regulatory proteins are non-uniform during spindle assembly, we asked if diffusiophoresis - motion of particles under solute gradients - can act as a motorless transport mechanism for microtubules. We identify the migration of stable microtubules along cytoplasmic and higher concentration gradients of soluble tubulin, MgCl, Mg-ATP, Mg-GTP, and RanGTP at speeds O(100) nm/s, validating the diffusiophoresis hypothesis.
View Article and Find Full Text PDFBackground: Islet or β-cell transplantation is a therapeutical approach to substitute the insulin-producing cells which are abolished in type 1 diabetes mellitus. The shortage of human islets as well as the complicated and costly isolation process limit the application of these techniques in daily clinical practice. EndoC-βH is a human β-cell line that readily forms aggregates termed pseudoislets, providing an alternative to primary human islets or β-cells.
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- * Molecular docking and simulations indicate that these candidates have a strong binding affinity to DPP4, maintaining stable interactions throughout a 200 ns simulation with observed H-bonding.
- * The findings suggest that these compounds could act as effective DPP4 inhibitors, potentially leading to new treatments for type 2 diabetes.