Publications by authors named "S Petros"
The most advanced monoclonal antibodies (mAbs) and vaccines against malaria target the central repeat region or closely related sequences within the circumsporozoite protein (PfCSP). Here, using an antigen-agnostic strategy to investigate human antibody responses to whole sporozoites, we identified a class of mAbs that target a cryptic PfCSP epitope that is only exposed after cleavage and subsequent pyroglutamylation (pGlu) of the newly formed N terminus. This pGlu-CSP epitope is not targeted by current anti-PfCSP mAbs and is not included in the licensed malaria vaccines.
View Article and Find Full Text PDFArticle Synopsis
- The proliferation of brain connectome data has allowed researchers to develop neural mass models that simulate whole brain activity, integrating interaction strength and tract lengths between regions.
- A new neural mass model derived from spiking cortical cell networks can account for both chemical and electrical synapses, demonstrating its capability to replicate functional connectivity patterns observed in neuroimaging studies.
- This study underlines the necessity of aligning theoretical models with biological principles and provides C++ code for efficient simulation of these neural mass networks, allowing for the exploration of delayed interactions within brain dynamics.
Total Thrombus-Formation System in Patients with Peripheral Artery Disease.
Clin Appl Thromb Hemost
November 2024
Article Synopsis
- The Total Thrombus-formation Analysis System (T-TAS) is an automated tool designed to evaluate thrombus (blood clot) formation under simulated blood flow conditions, particularly in patients receiving antiplatelet therapy.
- This study examined T-TAS's effectiveness in detecting responses to dual antiplatelet therapy (DAPT) among 60 patients with peripheral artery disease (PAD) after a surgical procedure.
- Findings indicated that the platelet-chip (PL-chip) of T-TAS was able to identify low responders to DAPT more effectively than traditional aggregation tests, suggesting it could be a useful tool for monitoring treatment responses in PAD patients.
Disbelief, Distress, & Distrust: Trending Institution Related Emotional Distress During COVID-19.
J Soc Work End Life Palliat Care
October 2024
The COVID-19 pandemic had an unprecedented impact on the well-being of individuals working in the healthcare sector. Though many studies exist that focus on physician and nurse well-being, few have specifically identified stressors that affect professionals working within the end-of-life interdisciplinary team. The primary objective of this study was to expand research on moral distress and clinician well-being to include healthcare professionals working with patients with chronic and life-limiting illnesses during the COVID-19 pandemic.
View Article and Find Full Text PDFBackground: Surviving sepsis can lead to chronic physical, psychological and cognitive impairments, which affect millions of patients worldwide, including survivors after COVID-19 viral sepsis. We aimed to characterize the magnitude and trajectory of functional dependence and new impairments post-sepsis.
Methods: We conducted a prospective cohort study including sepsis survivors who had been discharged from five German intensive care units (ICUs), until 36 months post-discharge.