Missing Medical Data in Neurological Emergency Care Compromise Patient Safety and Healthcare Resources.

Acute care of patients in the emergency department (ED) can be very challenging when patients attend EDs without their important medical information. This is especially problematic for multimorbid patients under polypharmacy. The aim of this study was to assess systematically the frequency and clinical relevance of incomplete medical data upon ED admission.

Plekhg5 controls the unconventional secretion of Sod1 by presynaptic secretory autophagy.

Increasing evidence suggests an essential function for autophagy in unconventional protein secretion (UPS). However, despite its relevance for the secretion of aggregate-prone proteins, the mechanisms of secretory autophagy in neurons have remained elusive. Here we show that the lower motoneuron disease-associated guanine exchange factor Plekhg5 drives the UPS of Sod1.

Increased projected changes in quasi-resonant amplification and persistent summer weather extremes in the latest multimodel climate projections.

High-amplitude quasi-stationary atmospheric Rossby waves with zonal wave numbers 6-8 associated with the phenomenon of quasi-resonant amplification (QRA) have been linked to persistent summer extreme weather events in the Northern Hemisphere. QRA is not well-resolved in current generation climate models, therefore, necessitating an alternative approach to assessing their behavior. Using a previously-developed fingerprint-based semi-empirical approach, we project future occurrence of QRA events based on a QRA index derived from the zonally averaged surface temperature field, comparing results from CMIP 5 and 6 (Coupled Model Intercomparison Project).

Narrative review of diagnosis, management and treatment of dysphagia and sialorrhea in amyotrophic lateral sclerosis.

The degenerative motor neuron disorder amyotrophic lateral sclerosis (ALS) frequently leads bulbar symptoms like dysarthria, dysphagia, and sialorrhea, in approximately one-third of cases being the initial symptom. Throughout the disease, more than two-thirds of ALS patients experience dysphagia, regardless of the region of onset. In this review, we aimed to offer an updated overview of dysphagia and sialorrhea in ALS, covering its diagnosis, monitoring, and treatment in clinical practice.