Administration of low doses of IL-2 combined to rapamycin promotes allogeneic skin graft survival in mice.

Human CD4(+) CD25(+) FoxP3(+) regulatory T cells (Tregs) prevent allogeneic graft rejection by inhibiting T cell activation, as has been shown in mouse models. Recently, low-dose IL-2 administration was shown to specifically activate Tregs but not pathogenic conventional T cells, leading to resolution of type 1 diabetes in nonobese diabetic mice. We therefore tested the ability of low-dose IL-2 to prevent allogeneic skin graft rejection.

[A practical example of the application of the "Belgian geriatric evaluation and management program" within a general hospital].

A concrete realisation of the "Geriatric assessment and management program" as described in the arrêté royal within a general hospital: definition of the geriatric patient, his detection, his follow-up and the transmission of patient information. The analysis of the first results indicates the importance of the biographic and socio-economics factors. The optimisation of an early screening and the communication between caregivers are key aspects to enhance the care of this patients.