Breaking the energy chain: importance of ATP synthase in and its potential as a drug target.

Unveiling novel pathways for drug discovery forms the foundation of a new era in the combat against tuberculosis. The discovery of a novel drug, bedaquiline, targeting mycobacterial ATP synthase highlighted the targetability of the energy metabolism pathway. The significant potency of bedaquiline against heterogeneous population of marks ATP synthase as an important complex of the electron transport chain.

In-hospital new-onset seizures in patients admitted to the medical intensive care unit: An observational study and algorithmic approach.

Background: Seizures are one of the most common neurological complications encountered in the intensive care unit (ICU). They can occur in the background of exacerbation of a known neurological disease or secondary to non-neurological conditions such as sepsis and metabolic disturbances. However, there is a paucity of literature on the incidence and pattern of new-onset seizures in ICUs.

A Covalent Chemical Probe for nsP2 Cysteine Protease with Antialphaviral Activity and Proteome-wide Selectivity.

RA-0003022 () was identified as a high-quality covalent chemical probe for nsP2 cysteine protease (nsP2pro). Isoxazole covalently captured the active site C478 and inactivated the enzyme with a / ratio of 6000 Ms. A negative control analog RA-0025453 () retained the covalent warhead but demonstrated >100-fold decrease in enzyme inhibition.

Elucidating the protective role of manganese seed priming in mitigating lead-induced oxidative stress: enhancements in growth, grain yield, and antioxidant activities of wheat.

Lead (Pb) is known to be extremely toxic to plants and awfully affects growth and productivity by interacting with morphological, biochemical, and physiological processes. Micronutrients are considered to reduce ion toxicity and modify various physiological processes involved in oxidative stress tolerance in plants. Hence, the limited literature about the application of micronutrients, particularly manganese (Mn), under lead stress thus demands more investigations.