Publications by authors named "S Perugu"
Article Synopsis
- - Breast cancer is a major cause of death in women, and issues like drug resistance due to genetic mutations complicate treatment; ResisenseNet is introduced as a solution that predicts drug sensitivity and resistance.
- - The model combines various methods, including a hybrid of 1D-CNN, LSTM, and DNN architectures, achieving a high validation accuracy of 0.9794 and showing effectiveness in analyzing transcription factors and amino acid sequences.
- - ResisenseNet has been tested on 14 cancers, highlighting certain drugs with potential against breast cancer, and found novel options with no previous anticancer activity, pointing to new treatment methods and improved strategies against drug resistance.
Background: Undergraduate (UG) medical students are one of the stakeholders and ultimate beneficiaries of the competency-based medical education (CBME) curriculum introduced in 2019 by the National Medical Commission (NMC). There is a dearth of literature on student perspectives on CBME Psychiatry clinical posting in India.
Methods: Second professional students who attended the psychiatry clinical posting were invited to participate in the qualitative study.
Background: The new competency-based medical education (CBME) curriculum presents an opportunity to address the many deficiencies in undergraduate (UG) psychiatry education in India. There are no published reports of such evaluations of psychiatry teaching programs based on the new CBME curriculum.
Methods: We performed a cross-sectional evaluation of the first clinical posting in psychiatry of the new CBME curriculum using the following metrics: clinical skills, knowledge, attitudes towards psychiatry, self-efficacy in performing the specific learning objectives (SLOs), and satisfaction with specific teaching-learning and assessment methods implemented.
Article Synopsis
- Cervical cancer is a leading cause of death among women, and traditional treatments are costly and have significant side effects, prompting the search for new options.
- The study identifies Betulin (BE), a triterpenoid, as a promising anti-cancer agent targeting key epigenetic proteins associated with cervical cancer through a series of advanced bioinformatics techniques.
- Preliminary findings suggest BE has better binding scores and favorable pharmacokinetic properties compared to standard drugs, indicating its potential effectiveness for further research, especially in live models.
Breast cancer, a highly formidable and diverse malignancy predominantly affecting women globally, poses a significant threat due to its intricate genetic variability, rendering it challenging to diagnose accurately. Various therapies such as immunotherapy, radiotherapy, and diverse chemotherapy approaches like drug repurposing and combination therapy are widely used depending on cancer subtype and metastasis severity. Our study revolves around an innovative drug discovery strategy targeting potential drug candidates specific to RTK signalling, a prominently targeted receptor class in cancer.
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