Publications by authors named "S Pereira-Simon"
Arteries and veins develop different types of occlusive diseases and respond differently to injury. The biological reasons for this discrepancy are not well understood, which is a limiting factor for the development of vein-targeted therapies. This study contrasts human peripheral arteries and veins at the single-cell level, with a focus on cell populations with remodeling potential.
View Article and Find Full Text PDFThe venous system has been historically understudied despite its critical roles in blood distribution, heart function, and systemic immunity. This study dissects the microanatomy of upper arm veins at the single cell level, and how it relates to wall structure, remodeling processes, and inflammatory responses to injury. We applied single-cell RNA sequencing to 4 non-diseased human veins (3 basilic, 1 cephalic) obtained from organ donors, followed by bioinformatic and histological analyses.
View Article and Find Full Text PDFIntroduction: The molecular transformation of the human preaccess vein after arteriovenous fistula (AVF) creation is poorly understood. This limits our ability to design efficacious therapies to improve maturation outcomes.
Methods: Bulk RNA sequencing (RNA-seq) followed by paired bioinformatic analyses and validation assays were performed in 76 longitudinal vascular biopsies (veins and AVFs) from 38 patients with stage 5 chronic kidney disease or end-stage kidney disease undergoing surgeries for 2-stage AVF creation (19 matured, 19 failed).
Article Synopsis
- The study investigates whether exosomal miRNAs from urine and lung tissue in individuals with idiopathic pulmonary fibrosis (IPF) carry disease-promoting signals that contribute to fibrosis.* -
- Researchers isolated exosomes from various sources (urine, lung myofibroblasts, serum) and analyzed their microRNA expression, finding consistent alterations related to IPF.* -
- The results show that these exosomes can induce a fibrotic response in skin and lung models, highlighting a systemic aspect of IPF where exosomal miRNAs interfere with tissue healing.*
Background: Systemic cytokines are elevated in patients with chronic kidney disease (CKD) and on hemodialysis compared with the general population. However, whether cytokine levels interfere with vascular remodeling, increasing the risk of arteriovenous fistula (AVF) failure, remains unknown.
Methods: This is a case-control study of 64 patients who underwent surgery for AVF creation (32 with AVF maturation failure and 32 matching controls with successful maturation).