Publications by authors named "S Pepple"
Article Synopsis
- This study investigates how different preprocessing pipelines for Diffusion Tensor Imaging (DTI) affect the estimation of nerve health metrics, addressing the issue of artifacts in echo-planar imaging.
- Researchers acquired DTI data from healthy volunteers and applied various correction methods, finding that while preprocessing enhances image similarity, it also leads to significant variability in the measurements of nerve health indicators across different pipelines.
- Ultimately, the study concludes that even though preprocessing improves certain aspects of image quality, the choice of pipeline can significantly affect crucial diffusion metrics, highlighting the need for careful methodology in DTI studies of peripheral nerves.
Retrograde intramedullary nailing or locked plating for stabilisation of distal femoral fractures? A comparative study of 193 patients.
Eur J Orthop Surg Traumatol
January 2024
Purpose: The aim of this study was to evaluate the results of distal femoral fracture fixation of two different methods, lateral locking plate (LP) or an Intra-medullary nail (IMN), in patients managed in our institution. More specifically, to assess: (a) if there was a difference in functional outcomes between the LP and IMN groups; (b) whether the rate of complications was different between the two groups.
Methods: Between January 2009 and December 2018 adult patients with distal femoral fractures managed in our unit with either LP or IMN for extra and intra-articular fractures were eligible to participate.
Opportunities arising from the COVID-19: an international orthopaedic surgeons' perspective.
Eur J Orthop Surg Traumatol
July 2023
Purpose: The unprecedented COVID-19 experience has posed severe challenges to the health care system and several of these are documented in orthopaedic surgery; however, although the pandemic has also brought positive changes, these have not been precisely documented. The purpose of this survey is to identify positive perceptions by orthopaedic surgeons at an international level.
Methods: A cross-sectional, web-based survey inviting 120 orthopaedic surgeons was conducted in April 2020 querying about the positive lessons COVID-19 would teach us.
Objective: To assess outcomes of repeat rituximab cycles and identify predictors of sustained clinical response in systemic manifestations of primary Sjögren syndrome (pSS).
Methods: An observational study was conducted in 40 rituximab-treated patients with pSS. Clinical response was defined as a 3-point or more reduction in the European League Against Rheumatism (EULAR) Sjögren Disease Activity Index (ESSDAI) at 6 months from baseline.