Publications by authors named "S Pence"
Heroin addiction is one of the neuropsychiatric burdens that affects many genetic and epigenetic systems. While it is known that heroin may change the expressions of some genes in the brain during dependence, there is no detailed study related to which gene are mostly affected. Therefore, in the current study, we aimed to determine alterations in the miRNA profiles of rats' brains for providing a detailed analysis of molecular mechanisms in heroin addiction-related toxicology.
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- The study highlights concerns over using general anesthesia in children under three, leading to the adoption of spinal anesthesia (SA) for pediatric urology, particularly for urgent neonatal testicular torsion.
- Data from six neonates undergoing SA for testicular torsion showed no complications, with a significant portion requiring orchiectomy of the affected testicle while successfully preserving the unaffected one.
- The findings support the safety and effectiveness of SA in these urgent procedures, suggesting its broader use for similar cases in neonatal patients.
Article Synopsis
- The study aimed to assess long-term urinary outcomes and incontinence management following the erosion of artificial urinary sphincters (AUS), focusing on related risk factors.
- Researchers analyzed data from 1943 patients who underwent AUS implantation, finding that 11% had device explantation due to erosion, with a median follow-up of 7.5 years.
- Key findings indicated that pelvic radiation and urethral reapproximation during explantation significantly increased the risk of developing urethral stricture, and while salvage AUS replacements were possible, they had a higher risk of re-erosion.
Objective: To evaluate the impact of a standardized perioperative pain management pathway on postoperative opioid prescribing practices following male perineal reconstructive surgery at our institution.
Methods: Patients undergoing perineal reconstructive surgery (urethroplasty, artificial urinary sphincter, urethral sling) by a single surgeon from July 2022 to June 2023 were prospectively followed. A standardized nonopioid pathway was implemented in the perioperative period.