Publications by authors named "S Peltonen"
The blood-brain barrier (BBB) serves as an interface between the bloodstream and the central nervous system. It limits the movement of molecules and immune cells, regulates the entry of nutrients, and removes waste products from the brain. The dysfunction of the BBB has been identified in Parkinson's disease (PD) but the role of the BBB and endothelial cells (ECs) has not been well studied.
View Article and Find Full Text PDFBackground: Darier disease is a genodermatosis which manifests as hyperkeratotic papules and superficial erosions mainly in seborrheic skin areas. This retrospective registry-based cohort study aimed to estimate the association between Darier disease and skin cancer.
Results: Patients diagnosed with Darier disease were identified from the patient registry of Sahlgrenska University Hospital (Gothenburg, Sweden) in 2016-2020.
Background: Pericytes play a crucial role in controlling inflammation and vascular functions in the central nervous system, which are disrupted in Parkinson's disease (PD). Still, there is a lack of studies on the impact of pericytes on neurodegenerative diseases, and their involvement in the pathology of PD is unclear. Our objective was to investigate the molecular and functional differences between healthy pericytes and pericytes with the LRRK2 G2019S mutation, which is one of the most common mutations associated with PD.
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- Microglia are immune cells in the brain that help maintain cellular health, but they might malfunction in Parkinson's disease (PD), particularly in relation to alpha-synuclein (αSyn) aggregation, which is a key feature of the disease.
- Research using human induced pluripotent stem cells showed that when microglia are exposed to both alpha-synuclein fibrils and inflammatory signals, it disrupts their ability to effectively manage and clear these aggregates.
- The study highlights that this model is useful for understanding microglial functioning in PD and reveals how inflammation affects their processing of alpha-synuclein, possibly worsening the disease state.
Various forms of oral involvement have been reported in patients with neurofibromatosis 1 (NF1). Here, we analyze register-based associations between NF1 and hospital visits related to oral infections. The Finnish NF1 cohort encompasses all individuals with verified NF1 who have visited the Finnish central and university hospitals in 1987-2011.
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