Will the Real Immunogens Please Stand Up: Exploiting the Immunogenic Potential of Cryptococcal Cell Antigens in Fungal Vaccine Development.

is an opportunistic fungal pathogen that is a continuous global health concern, especially for immunocompromised populations. The World Health Organization recognized as one of four critical fungal pathogens, thus emphasizing the need for increased research efforts and clinical resource expansion. Currently, there are no fungal vaccines available for clinical use.

Prostruc: an open-source tool for 3D structure prediction using homology modeling.

Introduction: Homology modeling is a widely used computational technique for predicting the three-dimensional (3D) structures of proteins based on known templates,evolutionary relationships to provide structural insights critical for understanding protein function, interactions, and potential therapeutic targets. However, existing tools often require significant expertise and computational resources, presenting a barrier for many researchers.

Methods: Prostruc is a Python-based homology modeling tool designed to simplify protein structure prediction through an intuitive, automated pipeline.

Macrobenthic assemblages of anthropogenically active subtidal zones contiguous to a marine protected area: a 9-year revisit.

Traditional taxonomical methods, an appropriate Benthic Biotic Index incorporating the Taxonomical Sufficiency concept and Biological Traits Analyses, were applied concurrently to evaluate the long-term variations in the benthic ecology of subtidal zones of a Marine-Protected Area subjected to prevalent oil and gas industrial activities. Our evaluation spanned two comparable surveys conducted 9 years apart (2010 vs. 2019).

Intravenous thrombolysis in a stroke patient with a repaired aortic dissection.

Acute aortic dissection is considered a contraindication to the use of intravenous thrombolysis in patients presenting with acute ischaemic stroke, but less has been described about previously repaired dissections. We present a case of a woman in her 50s presenting with acute left hemiparesis with a known history of aortic dissection within the thrombolysis window. After multidisciplinary discussion with cardiothoracic surgery and discussion with the patient, she was treated with intravenous thrombolysis without complication.

Evidence of natural lumpy skin disease virus (LSDV) infection and genetic characterization of LSDV strains from water buffaloes (Bubalus bubalis) in India.

Lumpy skin disease (LSD) has emerged as a threat to cattle production in Asia, and India has been facing LSD epidemics since 2019. Although water buffalo (Bubalus bubalis) is susceptible to natural LSDV infection, there have been no confirmed reports of LSDV infection in water buffalo in India. In this study, we investigated suspected cases of LSD in water buffaloes from 12 Indian states and one union territory during 2020-2023.