Identifying candidate RNA-seq biomarkers for severity discrimination in chemical injuries: A machine learning and molecular dynamics approach.

Introduction: Biomarkers play a crucial role across various fields by providing insights into biological responses to interventions. High-throughput gene expression profiling technologies facilitate the discovery of data-driven biomarkers through extensive datasets. This study focuses on identifying biomarkers in gene expression data related to chemical injuries by mustard gas, covering a spectrum from healthy individuals to severe injuries.

Impact of Year and Genotype on Benzoxazinoids and Their Microbial Metabolites in the Rhizosphere of Early-Vigour Wheat Genotypes in Southern Australia.

Wheat () is grown on more arable acreage than any other food crop and has been well documented to produce allelochemicals. Wheat allelochemicals include numerous benzoxazinoids and their microbially transformed metabolites that actively suppress growth of weed seedlings. Production and subsequent release of these metabolites by commercial wheat cultivars, however, has not yet been targeted by focussed breeding programmes seeking to develop more competitive crops.

Who Is responsible for the Opioid Crisis? A Discourse Analysis of Responsibility Claims in Medicine.

The opioid crisis has continued despite efforts to intervene on its identified causes. In this article, we analyse responsibility claims in pain and addiction medical journals concerning the opioid crisis. Selected journals represent the opioid crisis as a medical problem.

Tailored Ni(OH)/CuCo/Ni(OH) Composite Interfaces for Efficient and Durable Urea Oxidation Reaction.

Electrocatalytic urea oxidation reaction is a promising alternative to water oxidation for more efficient hydrogen production due to its significantly lower thermodynamic potential. However, achieving efficient electrochemical urea oxidation remains a formidable challenge, and development of an improved electrocatalyst with an optimal physicochemical and electronic structure toward urea oxidation is desired. This can be accomplished by designing a tailored two-dimensional composite with an abundance of active sites in a favorable electronic environment.

From Mild Cases to Critical Cases of COVID-19: The Role of Genes in Inflammasome and Mitochondrial Dynamics.

The coronavirus disease 2019 (CVOID-19) has varied clinical manifestations including mild to severe acute respiratory symptoms. Inflammasome complex and mitochondria play an important role in initiating inflammatory responses and could potentially be affected by this infection. To study the inflammasome and mitochondrial fission and fusion gene expression levels in COVID-19 patients, we designed this experiment.