A new approach to ring-opening polymerization (ROP) based on C(sp)-C(sp) bond cleavage is reported. This process is based on the ability of Pd to promote both the β-carbon elimination of a bifunctional cyclobutanol precursor and the C-C coupling process with the resulting Pd-alkyl intermediate. Consequently, novel polyketone materials are obtained.
View Article and Find Full Text PDFIn this work, we describe the unexpected 2-fold Csp-Csp bond cleavage suffered by cyclobutanols in the presence of a catalytic amount of Pd(OAc) and promoted by the bulky biaryl JohnPhos ligand. Overall, the sequential cleavage of a strained and an unstrained Csp-Csp bond leads to the formal [2 + 2]-retrocyclization products, namely, styrene and acetophenone derivatives. This procedure might enable the use of cyclobutanols as masked acetyl groups, resisting harsh conditions in organic synthesis.
View Article and Find Full Text PDFObjective: To describe the planning and execution process of a massive seroprevalence study for SARS-CoV-2 in professionals of the Hospital Universitario Fundación Alcorcón (HUFA) (Spain).
Methods: A description is presented of the plan designed and developed at the HUFA for the execution of the extraction of the samples for serology from all the professionals who worked in the hospital between 14 and 29 April 2020. A descriptive analysis of the participation of the professionals in the study is carried out.