Age-related Differences in Response Inhibition Are Mediated by Frontoparietal White Matter but Not Functional Activity.

Healthy older adults often exhibit lower performance but increased functional recruitment of the frontoparietal control network during cognitive control tasks. According to the cortical disconnection hypothesis, age-related changes in the microstructural integrity of white matter may disrupt inter-regional neuronal communication, which in turn can impair behavioral performance. Here, we use fMRI and diffusion-weighted imaging to determine whether age-related differences in white matter microstructure contribute to frontoparietal over-recruitment and behavioral performance during a response inhibition (go/no-go) task in an adult life span sample (n = 145).

TAG-ME again: A serious game for measuring working memory.

BrainTagger (demo version: researcher-demo.braintagger.com) is a suite of Target Acquisition Games for Measurement and Evaluation (TAG-ME).

Are older adults susceptible to visual distraction when targets and distractors are spatially separated?

Older adults show preserved memory for previously distracting information due to reduced inhibitory control. In some previous studies, targets and distractors overlap both temporally and spatially. We investigated whether age differences in attentional orienting and disengagement affect recognition memory when targets and distractors are spatially separated at encoding.

The role of anterior and medial dorsal thalamus in associative memory encoding and retrieval.

A growing body of work has revealed a role for the anterior and medial dorsal thalamus in memory. Very few studies, however, have used neuroimaging to test hypotheses regarding these structures' predicted roles in associative memory encoding and retrieval. To fill this gap, our study used fMRI in a group of healthy adults as they performed a face-scene associative memory task.