Risk of harboring an unruptured intracranial aneurysm.

Background And Purpose: The purpose of the present study was to calculate the prevalence and relative risk of unruptured incidental intracranial aneurysms (IAs) among families with IA case(s) compared with the general population in one geographically defined area in East Finland and to identify the risk group that could benefit most from screening for IAs. We compared these results with our earlier study results of familial IA (FIA) cases, with two or more known IA cases in the same family.

Methods: The study groups were collected from the catchment area of the University Hospital of Kuopio in East Finland.

Nucleolar organizer regions in myofibroblasts in breast cancer. Relation to cancer cell morphometry, flow cytometry, sex steroid receptor content, tumour histology and prognosis.

The number of silver-stained nucleolar organizer regions (Ag-NORs) was counted in stromal myofibroblasts in 125 cases of breast cancer. The mean (S.E.

Mast cells in breast cancer.

The number of stromal mast cells was counted in 187 breast carcinomas. The number of mast cells/mm2 of tumour stroma was studied in relation to clinical, histological and quantitative prognostic factors and survival. A high number of mast cells in tumour stroma was significantly related to low S phase fraction (p = 0.

Young breast-cancer patients have unfavorable prognosis because of biologically aggressive tumors.

A retrospective analysis of 418 breast cancer patients was done to investigate the differencies in survival, in clinical and in histopathological variables between the different age groups giving special attention to young women. Three age groups were used, young (age less-than-or-equal-to 40 years), middle-aged (41-50 years) and elderly women (>50 years). The tumours in young women had high mitotic activity (p<0.

Proliferating-cell nuclear antigen (PC10) immunolabelling and other proliferation indices as prognostic factors in breast cancer.

Proliferating cell nuclear antigen, PCNA (PC10), immunolabelling was determined in 175 women with breast carcinomas and related to other established prognostic factors: flow-cytometric data, volume-corrected mitotic index, sex steroid receptor content and clinical outcome during the mean follow-up of 9 years. The maximum fraction of PCNA-positive nuclei (PCNAmax), the average fraction of positive nuclei (PCNAtot) and the number of intensely stained nuclei per microscope field (PCNAcount) were significantly related to histological grade (P < 0.001), DNA ploidy ((P < 0.