Engineering proteins with catechol chemistry for biotechnological applications.

Developing proteins with increased chemical space by expanding the amino acids alphabet has been an emerging technique to compete for the obstacle encountered by their need in various applications. 3,4-Dihydroxyphenylalanine (L-DOPA) catecholic unnatural amino acid is abundantly present in mussels foot proteins through post-translational modification of tyrosine to give a strong adhesion toward wet rocks. L-DOPA forms: bidentate coordination, H-bonding, metal-ligand complexes, long-ranged electrostatic, and van der Waals interactions a pair of donor hydroxyl groups.

Lessons Learned From a Peer-Supported Differentiated Care and Nutritional Supplementation for People With TB in a Southern Indian State.

Two critical components of patient support systems for people with TB are regular counseling and locally managed nutritional support. As part of an ongoing differentiated TB care initiative called Tamil Nadu Kasanoi Erappila Thittam (meaning TB death-free initiative in Tamil, TN-KET) to reduce TB deaths, adults with TB with very severe undernutrition, respiratory insufficiency, or poor performance status are identified at diagnosis (triage-positive) and prioritized for referral, comprehensive clinical assessment, and inpatient care. Between January and June 2023, in 6 districts, a pilot exercise was conducted in which trained TB survivors, known as TB champions, provided baseline counseling and additional counseling (if required) to triage-positive people with TB at diagnosis.

Yoked prisms and cerebral visual impairment: Enhancing the experience of ambient vision.

Background: Perceptual visual impairment leads to impaired functional vision in children with cerebral visual impairment. Yoked prisms have been used in behavioral vision therapy for children with autism (dysfunctional dorsal visual processing pathway) and in neurorehabilitation to treat visual neglect, hemianopia, and abnormal egocentric localization. In particular, they are employed for treating perceptual visual problems.

An uncommon presentation of WAGR syndrome with persistent fetal vasculature.

Aniridia is an autosomal dominant congenital malformation associated with mutations in the PAX6 gene. It can be associated with deletion in the contiguous WT1 gene, leading to WAGR syndrome, characterized by Wilm tumor, aniridia, genitourinary anomalies, and mental retardation. Persistent fetal vasculature is a developmental malformation caused by incomplete regression of hyaloid vasculature.

Evaluation of Postoperative Outcome and Incidence of Complications in Multisegment Le Fort I Osteotomies: A Case Series.

Orthognathic surgeries are considered successful on the basis of postoperative stability, vascularity, and relapse rates. One among them is the multisegment Le Fort I osteotomy, which has often been disregarded due to vascular compromise. The complications associated with such an osteotomy are also primarily due to vascular ischemia.