Impact of the geriatric emergency medicine specialist intervention on final emergency department disposition.

Background: The Geriatric Emergency Medicine Specialist (GEMS) pilot program is an innovative approach that utilizes geriatric-trained advanced practice providers to facilitate geriatric assessments and care planning for older adults in the emergency department (ED). The objective of this study was to explore the effect of GEMS on the use of observation status and final ED disposition.

Methods: This was a retrospective study under a target trial emulation framework.

Young transgenic hMTH1 mice are protected against dietary fat-induced metabolic stress-implications for enhanced longevity.

hMTH1 protects against mutation during oxidative stress. It degrades 8-oxodGTP to exclude potentially mutagenic oxidized guanine from DNA. hMTH1 expression is linked to ageing.

Advanced Raman Spectroscopy Detection of Oxidative Damage in Nucleic Acid Bases: Probing Chemical Changes and Intermolecular Interactions in Guanosine at Ultralow Concentration.

DNA/RNA synthesis precursors are especially vulnerable to damage induced by reactive oxygen species occurring following oxidative stress. Guanosine triphosphates are the prevalent oxidized nucleotides, which can be misincorporated during replication, leading to mutations and cell death. Here, we present a novel method based on micro-Raman spectroscopy, combined with calculations, for the identification, detection, and quantification of oxidized nucleotides at low concentration.

Emerging oxidized and defective phases in low-dimensional CrCl.

Two-dimensional (2D) magnets such as chromium trihalides CrX (X = I, Br, Cl) represent a frontier for spintronics applications and, in particular, CrCl has attracted research interest due its relative stability under ambient conditions without rapid degradation, as opposed to CrI. Herein, mechanically exfoliated CrCl flakes are characterized at the atomic scale and the electronic structures of pristine, oxidized, and defective monolayer CrCl phases are investigated employing density functional theory (DFT) calculations, scanning tunneling spectroscopy (STS), core level X-ray photoemission spectroscopy (XPS), and valence band XPS and ultraviolet photoemission spectroscopy (UPS). As revealed by atomically resolved transmission electron microscopy (TEM) and energy dispersive X-ray (EDX) analysis, the CrCl flakes show spontaneous surface oxidation upon air exposure with an extrinsic long-range ordered oxidized O-CrCl structure and amorphous chromium oxide formation on the edges of the flakes.