Exploring modified chitosan-based gene delivery technologies for therapeutic advancements.

One of the critical steps in gene therapy is the successful delivery of the genes. Immunogenicity and toxicity are major issues for viral gene delivery systems. Thus, non-viral vectors are explored.

Synthesis, physical, chemical, biological, mechanical and electronic studies of polypyrrole (PPy) of versatile scales for electro-mechano, pharmaceutical utilities.

The Polypyrrole is properly synthesized with the customary ammonium persulphate as an oxidizing agent. The number of reactions for versatile molar ratios (oxidant: monomer) is addressed and pronounced. Powder X-ray diffraction (XRD) analysis revealed the material amorphous nature by wide peak from 20° to 30°.

Construction of an efficient Escherichia coli whole-cell biocatalyst for D-mannitol production.

Mannitol is a six carbon sugar alcohol that finds applications in the pharmaceutical and food industries. A novel Escherichia coli strain capable of converting D-glucose to D-mannitol has been constructed, wherein native mannitol-1-phosphate dehydrogenase (MtlD) and codon-optimized Eimeria tenella mannitol-1-phosphatase (M1Pase) have been overexpressed. Codon-optimized Pseudomonas stutzeri phosphite dehydrogenase (PtxD) was overexpressed for cofactor (NADH) regeneration with the concomitant oxidation of phosphite to phosphate.

Subarachnoid haemorrhage: possibly caused by the illegitimate use of sildenafil citrate.

Sildenafil (Viagra) has been developed as a drug to treat male impotence. It has also been used to reduce symptoms (e.g.