Publications by authors named "S PEPI"
Polyvinyl alcohol (PVA), possessing a strong ability to form hydrogels, has been widely used for various pharmaceutical and biomedical applications. In particular, the use of PVA-PEG in the form of theta gels for altered cartilage treatment has attracted an enormous amount of attention in the last 20 years. In this paper, we prepared 42 PVA-PEG in the form of theta gels at room temperature in an aqueous environment, testing the crystallization occurrence at basic pH (10 or 12).
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- The study utilized click chemistry, specifically CuAAC, to create crosslinked derivatives of hyaluronan-based graft copolymers under mild conditions using ferulic acid and novel azido-terminated crosslinking agents.
- Characterization of the resulting materials was conducted through NMR, TGA, and DSC analyses to assess their structural properties, swelling behavior, and gel-like characteristics.
- The crosslinked materials demonstrated superior swelling performance, shear-thinning behavior, and significantly higher enzymatic resistance compared to commercial viscosupplements, suggesting their potential use as innovative viscosupplements.
Natamycin is a tetraene polyene that exploits its antifungal properties by irreversibly binding components of fungal cell walls, blocking the growth of infections. However, topical ocular treatments with natamycin require frequent application due to the low ability of this molecule to permeate the ocular membrane. This limitation has limited the use of natamycin as an antimycotic drug, despite it being one of the most powerful known antimycotic agents.
View Article and Find Full Text PDFGlaucoma represents a group of neurodegenerative diseases characterized by optic nerve damage and the slowly progressive death of retinal ganglion cells. Glaucoma is considered the second leading cause of irreversible blindness worldwide. Pharmaceutical treatment of glaucoma is critical because of the properties of the ocular barrier that limit the penetration of drugs, resulting in lower systemic bioavailability.
View Article and Find Full Text PDFNew graft copolymers were prepared by reaction of poly (vinyl alcohol) (PVA) with mono-imidazolide or bis-imidazolide derivatives of ferulic acid (FA) with the formation of ester bonds. The obtained graft copolymers, thanks to the crosslinking capability of FA, formed in water strong gels as verified by rheological analyses. The resulting hydrogels were characterized to evaluate their applicability as wound dressing.
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