Publications by authors named "S P van der Werf"
Article Synopsis
- Understanding how viruses like influenza A interact with cellular processes can help develop treatments targeting host cells.
- Researchers found that specific components of the Cullin 4-RING E3 ubiquitin ligases (CRL4), essential for virus replication, change their interactions during infection.
- The study revealed that IAV infection alters protein associations, impacting cellular functions such as protein folding and stress responses, which could lead to new antiviral strategies.
Background: Pacific Islanders are underrepresented in vaccine efficacy trials. Few studies describe their immune response to COVID-19 vaccination. Yet, this characterization is crucial to re-enforce vaccination strategies adapted to Pacific Islanders singularities.
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- The European Society for Blood and Marrow Transplantation (EBMT) has established a continental registry over 30 years, currently housing data on over 700,000 patients and 800,000 transplants, which supports various research and benchmarking efforts in hematopoietic cell transplantation.
- The introduction of CAR-T cell therapies, which could significantly impact blood and marrow transplantation practices, prompted EBMT to create a Cellular Therapy Form that registers CAR-T cell treated patients and collects detailed outcome data.
- The EBMT Registry received approval from the European Medicines Agency in 2019 and now holds information on more than 9,000 patients treated with CAR-T cells, facilitating analyses and evaluations of these therapies' medical value within different contexts
Article Synopsis
- Antibodies are crucial for defense against SARS-CoV-2, but their effectiveness is threatened by new viral variants.
- Two specific broadly neutralizing antibodies, Cv2.3194 and Cv2.3132, were identified from the memory B cells of an individual who recovered from the original SARS-CoV-2 infection.
- When used together, these antibodies exhibit a synergistic effect that enhances their ability to neutralize SARS-CoV-2, indicating that strong immune responses from previous infections can still be effective against evolving virus strains.
Introduction: Itch is one of the most burdensome symptoms in epidermolysis bullosa (EB), indicating a hitherto unmet therapeutic need. This review leverages existing data on efficacy of itch treatment in EB to support sound decision making.
Methods: A systematic literature search was performed on 29 March 2022.