Publications by authors named "S P van Vuuren"
Aims: Antimicrobial resistance continues to be a growing concern, resulting in increased use of drug combinations. Antibiotic adjuvants are an emerging strategy that may potentiate an antibiotics efficacy. Ibuprofen's polypharmacological properties have been investigated for their antimicrobial and host-modulating potential.
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- Diabetic foot syndrome involves diabetic foot ulcers and is complicated by factors like neuropathy and infections, making it challenging to choose effective antimicrobial treatments, especially due to multidrug-resistant infections.
- In South Africa, treatment protocols for these infections rely on general guidelines that may not reflect local bacterial behavior, prompting the need for research to tailor more effective treatments.
- A study analyzing 51 samples found that gentamicin and ciprofloxacin were the most effective antibiotics, while traditional first-line treatments were often ineffective against commonly isolated pathogens such as Proteus mirabilis and Pseudomonas aeruginosa.
Aims: This study aimed to explore potential synergistic effects of medicinal dyes with antimicrobials against pathogens responsible for skin infections.
Methods And Results: Antimicrobial testing was conducted using minimum inhibitory concentrations and minimum bactericidal/fungicidal concentration assays. The fractional inhibitory index (ΣFIC) of combinations was calculated, and isobolograms were constructed on selected combinations.
Ethnopharmacological Relevance: Numerous medicinal plants have been used traditionally in South Africa for gastric ulcer treatment. Helicobacter pylori is known for causing inflammation and the onset of gastric ulcers. While several studies explored medicinal plants against H.
View Article and Find Full Text PDFAntimicrobial resistance has emerged as a significant threat to public health, prompting novel combinations comprising of natural sources such as essential oil compounds with conventional antibiotics. This study aimed to determine the possible interactions between six essential oil compounds with eight antibiotics/antifungals against six pathogens (, , , , , and ) commonly implicated in skin infections. The minimum inhibitory concentrations (MICs) for the antibiotics and essential oil compounds were evaluated singularly and in combination using the broth microdilution assay.
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