Influence of coal gangue-aeolian sand aggregate gradation on rheological properties and pipeline transportation characteristics of filling slurry.

Uneven of filling aggregate gradation may cause transportation problems such as pipe blockage due to segregation and stratification of filling slurry. To study the influence of aggregate gradation on the conveying performance of filler slurry, aggregate gradation experiments were carried out, rheological tests on slurries with coal gangue/aeolian sand ratios (6:4, 5:5 and 4:6) showed that appropriately increasing the proportion of aeolian sand can improve particle gradation. Computational fluid dynamics (CFD) scheme was used to simulate the pipeline transportation characteristics of the slurry under the conditions of three sets each of coal gangue/aeolian sand ratios, slurry concentrations (72%,74% and 76%), and inlet velocities (1.

Effect of radiotherapy exposure on fruquintinib plus sintilimab treatment in refractory microsatellite stable metastatic colorectal cancer: a prospective observation study.

Background: Immune checkpoint inhibitors (ICIs) in combination with antiangiogenic drugs have shown promising outcomes in the third-line and subsequent treatments of patients with microsatellite stable metastatic colorectal cancer (MSS-mCRC). Radiotherapy (RT) may enhance the antitumor effect of immunotherapy. However, the effect of RT exposure on patients receiving ICIs and targeted therapy remains unclear.

Chermesins I-N: Bioactive spiromeroterpenoids from the marine-sourced fungus Penicillium chermesinum AS-400.

Six previously undescribed spiromeroterpenoids, chermesins I-N (1-6), were isolated and identified from the marine-sourced fungus Penicillium chermesinum AS-400. Their structures were determined by nuclear magnetic resonance and mass spectroscopic data, and the relative and absolute configurations were confirmed based on nuclear Overhauser effect spectroscopic experiments, electronic circular dichroism (ECD) calculations and X-ray crystallographic analysis, and by comparisons of ECD Cotton effects with those of known congeners as well. Structurally, compound 1 represents the first example of spiromeroterpenoid demethylated at C-4.

Antimicrobial polyketides from the endophytic fungus Fusarium asiaticum QA-6 derived from medicinal plant Artemisia argyi.

Seven previously undescribed polyketide derivatives, fusariumtides A-G (1-7), together with three known analogues (8-10), were isolated from the culture extract of Fusarium asiaticum QA-6, an endophytic fungus obtained from the fresh stem tissue of the medicinal plant Artemisia argyi H. Lev. & Vaniot.

Decoding the difference of four species of Cordyceps based on polysaccharides and immunomodulation activity.

Nucleosides and polysaccharides are the main bioactive ingredients of Cordyceps genus. Nucleosides shows significant differences in different Cordyceps species. However, the differences of polysaccharides have not been decoded.