Publications by authors named "S P Willemsen"
Background: Physiological-based cord clamping (PBCC) in preterm infants is beneficial for cardiovascular transition at birth and may optimize placental transfusion. Whether PBCC can improve clinical outcomes is unknown. The aim of the Aeration, Breathing, Clamping (ABC3) trial was to test whether PBCC results in improved intact survival in very preterm infants.
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- The study focuses on how the intake of polyunsaturated fatty acids (PUFAs) during the periconceptional period affects embryonic development, particularly embryonic volume (EV) and head volume (HV) in pregnant women.* -
- Findings reveal that many women have low omega-3 intake, and while higher PUFA intake is linked to a smaller HV/EV ratio, it does not correlate with individual EV or HV growth measures.* -
- The research highlights a significant omega-3 deficiency in pregnant women and emphasizes the need for better awareness of PUFA intake to mitigate risks of negative pregnancy outcomes.*
Developing an effective and simple digital screening tool to identify inadequate calcium intake in pregnant women: A prediction model in the Rotterdam periconception cohort.
Eur J Obstet Gynecol Reprod Biol
November 2024
Objectives: An inadequate intake of calcium in pregnancy is associated with higher risks of maternal hypertensive pregnancy disorders, premature birth and intrauterine growth restriction. An evidence based and clinically applicable tool to efficiently estimate the adequacy of calcium intake in pregnant women currently does not exist. The aim of this study is to develop an effective and simple digital screening tool for calcium intake in pregnancy.
View Article and Find Full Text PDFIntroduction: Maternal lifestyle behaviours can affect blood pressure with consequences for maternal and offspring health. The aim of this study was to investigate the effectiveness of the Smarter Pregnancy digital lifestyle coaching program on maternal blood pressure during the first trimester.
Methods: The study was conducted on data of the Rotterdam Periconception Cohort from 2010 to 2019 (analysis completed in 2024).
Article Synopsis
- Nuclear receptors (NRs) are important transcription factors in the small intestine that respond to various signals and influence multiple biological processes such as nutrient absorption and drug metabolism.
- This study examines the activation of six different NRs using small molecule agonists in human intestinal organoids, highlighting their roles in lipid, glucose, and amino acid absorption, as well as electrolyte balance.
- Unique target genes associated with specific NRs were identified, providing valuable insights that could lead to enhanced pharmacological and therapeutic applications.